Drug Information

Drug General Information
Drug ID
D0U9QD
Former ID
DIB018676
Drug Name
6-fluorotryptophan
Drug Type
Small molecular drug
Indication Discovery agent Investigative [468191]
Structure
Download
2D MOL
Formula
C11H11FN2O2
InChI
InChI=1S/C11H11FN2O2/c12-7-1-2-8-6(3-9(13)11(15)16)5-14-10(8)4-7/h1-2,4-5,9,14H,3,13H2,(H,15,16)
InChIKey
YMEXGEAJNZRQEH-UHFFFAOYSA-N
PubChem Compound ID
94937
PubChem Substance ID
74861, 3134937, 5199198, 10226852, 15341314, 24894946, 44425478, 48496152, 49747511, 50059061, 53792613, 57335951, 77219520, 85086155, 87619219, 103617497, 103805920, 104414045, 117543473, 117650867, 124573739, 125374298, 125813741, 126693443, 129815767, 135051483, 135076321, 135377016, 137088228, 142422778, 143465140, 152055851, 162087408, 162205300, 162362853, 163132047, 163788981, 164805270, 169350930, 174537006, 178101819, 179325543, 184021893, 184588075, 186003757, 187567765, 202565312, 206251036, 224520457, 226598318
Target and Pathway
Target(s) L-Tryptophan hydroxylase 2 Target Info Inhibitor [533554]
Tryptophan 5-hydroxylase-1 Target Info Inhibitor [533554]
BioCyc Pathway Superpathway of tryptophan utilization
Serotonin and melatonin biosynthesis
KEGG Pathway Tryptophan metabolism
Metabolic pathways
Serotonergic synapse
PANTHER Pathway 5-Hydroxytryptamine biosynthesis
PathWhiz Pathway Tryptophan Metabolism
WikiPathways SIDS Susceptibility Pathways
Biogenic Amine Synthesis
Tryptophan metabolism
Metabolism of amino acids and derivatives
References
Ref 468191(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5126).
Ref 533554(+)-6-fluorotryptophan, an inhibitor of tryptophan hydroxylase: sleep and wakefulness in the rat. Neuropharmacology. 1981 Apr;20(4):335-9.

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