Drug Information

Drug General Information
Drug ID
D0J9TD
Former ID
DNC013212
Drug Name
N-biphenyl-3-ylmethyl-N'-hydroxy-malonamide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528703]
Structure
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2D MOL

3D MOL
Formula
C16H16N2O3
Canonical SMILES
C1=CC=C(C=C1)C2=CC(=CC=C2)CNC(=O)CC(=O)NO
InChI
1S/C16H16N2O3/c19-15(10-16(20)18-21)17-11-12-5-4-8-14(9-12)13-6-2-1-3-7-13/h1-9,21H,10-11H2,(H,17,19)(H,18,20)
InChIKey
FKVBZDLUQPPZNE-UHFFFAOYSA-N
PubChem Compound ID
16116574
Target and Pathway
Target(s) Aminopeptidase N Target Info Inhibitor [528703]
BioCyc Pathway Glutathione-mediated detoxification
KEGG Pathway Glutathione metabolism
Metabolic pathways
Renin-angiotensin system
Hematopoietic cell lineage
Pathway Interaction Database C-MYB transcription factor network
PathWhiz Pathway Glutathione Metabolism
Reactome Metabolism of Angiotensinogen to Angiotensins
WikiPathways Metabolism of Angiotensinogen to Angiotensins
Cardiac Progenitor Differentiation
miR-targeted genes in squamous cell - TarBase
miR-targeted genes in muscle cell - TarBase
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in leukocytes - TarBase
Glutathione metabolism
References
Ref 528703J Med Chem. 2007 Mar 22;50(6):1322-34. Epub 2007 Feb 28.Novel selective inhibitors of the zinc plasmodial aminopeptidase PfA-M1 as potential antimalarial agents.
Ref 528703J Med Chem. 2007 Mar 22;50(6):1322-34. Epub 2007 Feb 28.Novel selective inhibitors of the zinc plasmodial aminopeptidase PfA-M1 as potential antimalarial agents.

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