Drug Information

Drug General Information
Drug ID
D06CSI
Former ID
DNC014829
Drug Name
Alpha,beta-methylene-dTTP
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529712]
Structure
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2D MOL

3D MOL
Formula
C11H19N2O13P3
Canonical SMILES
CC1=CN(C(=O)NC1=O)C2CC(C(O2)COP(=O)(CP(=O)(O)OP(=O)(O)O<br />)O)O
InChI
1S/C11H19N2O13P3/c1-6-3-13(11(16)12-10(6)15)9-2-7(14)8(25-9)4-24-27(17,18)5-28(19,20)26-29(21,22)23/h3,7-9,14H,2,4-5H2,1H3,(H,17,18)(H,19,20)(H,12,15,16)(H2,21,22,23)/t7-,8+,9+/m0/s1
InChIKey
AFUOLHFRDGMFSB-DJLDLDEBSA-N
PubChem Compound ID
15667207
Target and Pathway
Target(s) DNA polymerase Target Info Inhibitor [529712]
References
Ref 529712J Med Chem. 2008 Oct 23;51(20):6460-70. Epub 2008 Sep 24.Alpha,beta-methylene-2'-deoxynucleoside 5'-triphosphates as noncleavable substrates for DNA polymerases: isolation, characterization, and stability studies of novel 2'-deoxycyclonucleosides, 3,5'-cyclo-dG, and 2,5'-cyclo-dT.
Ref 529712J Med Chem. 2008 Oct 23;51(20):6460-70. Epub 2008 Sep 24.Alpha,beta-methylene-2'-deoxynucleoside 5'-triphosphates as noncleavable substrates for DNA polymerases: isolation, characterization, and stability studies of novel 2'-deoxycyclonucleosides, 3,5'-cyclo-dG, and 2,5'-cyclo-dT.

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