Drug Information

Drug General Information
Drug ID
D0O2KO
Former ID
DNC002421
Drug Name
N-Omega-Propyl-L-Arginine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [541653]
Structure
Download
2D MOL

3D MOL
Formula
C9H20N4O2
InChI
InChI=1S/C9H20N4O2/c1-2-5-12-9(11)13-6-3-4-7(10)8(14)15/h7H,2-6,10H2,1H3,(H,14,15)(H3,11,12,13)/t7-/m0/s1
InChIKey
AOMXURITGZJPKB-ZETCQYMHSA-N
PubChem Compound ID
447180
PubChem Substance ID
831296, 831303, 11113951, 14822566, 36889404, 78180692, 99007974, 99376159, 103327068, 104098434, 104637620, 127436488, 135371226, 137132959, 152051085, 160965821, 163122834, 176224196, 178103139, 204366575, 223536049, 227258974, 241033624, 241182224, 250136972, 252468708
Target and Pathway
Target(s) Nitric oxide synthase, inducible Target Info Inhibitor [551393]
Nitric-oxide synthase, brain Target Info Inhibitor [551393]
BioCyc Pathway Citrulline-nitric oxide cyclePWY-4983:Citrulline-nitric oxide cycle
KEGG Pathway Arginine biosynthesis
Arginine and proline metabolism
Metabolic pathways
Calcium signaling pathway
HIF-1 signaling pathway
Peroxisome
Salmonella infection
Pertussis
Leishmaniasis
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Amoebiasis
Tuberculosis
Pathways in cancer
Small cell lung cancerhsa00330:Arginine and proline metabolism
Phagosome
Circadian entrainment
Long-term depression
Salivary secretion
Alzheimer's disease
Amyotrophic lateral sclerosis (ALS)
NetPath Pathway IL1 Signaling Pathway
IL2 Signaling PathwayNetPath_4:EGFR1 Signaling Pathway
PANTHER Pathway CCKR signaling map ST
Pathway Interaction Database IL12-mediated signaling events
Alpha9 beta1 integrin signaling events
ATF-2 transcription factor network
IL23-mediated signaling events
Signaling mediated by p38-alpha and p38-beta
HIF-1-alpha transcription factor network
PathWhiz Pathway Arginine and Proline Metabolism
Reactome ROS production in response to bacteria
Nitric oxide stimulates guanylate cyclaseR-HSA-1222556:ROS production in response to bacteria
Nitric oxide stimulates guanylate cyclase
WikiPathways Type II interferon signaling (IFNG)
Spinal Cord Injury
AGE/RAGE pathway
Effects of Nitric OxideWP727:Monoamine Transport
Myometrial Relaxation and Contraction Pathways
Amyotrophic lateral sclerosis (ALS)
Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis
Alzheimers Disease
Effects of Nitric Oxide
Serotonin Transporter Activity
References
Ref 541653(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6525).
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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