Drug Information

Drug General Information
Drug ID
D05VOG
Former ID
DIB018796
Drug Name
AL-8810
Synonyms
AL8810; AL 8810
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539253]
Structure
Download
2D MOL
Formula
C24H31FO4
InChI
InChI=1S/C24H31FO4/c25-21-15-23(27)20(9-3-1-2-4-10-24(28)29)19(21)11-12-22(26)18-13-16-7-5-6-8-17(16)14-18/h1,3,5-8,11-12,18-23,26-27H,2,4,9-10,13-15H2,(H,28,29)/b3-1-,12-11+/t19-,20-,21+,22+,23+/m1/s1
InChIKey
WTYSXBKKVNOOIX-JTGCGUAKSA-N
PubChem Compound ID
5311238
PubChem Substance ID
7979766, 11056369, 17404610, 24278225, 39340946, 53777152, 57359403, 78160083, 90340743, 92303427, 114155637, 121361422, 124749402, 125240973, 135277244, 135649914, 142154512, 163564432, 198936236, 241054576, 242146037, 252451289, 252457260
Target and Pathway
Target(s) Prostaglandin F2-alpha receptor Target Info Agonist [525568]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Reactome Prostanoid ligand receptors
G alpha (q) signalling events
WikiPathways Prostaglandin Synthesis and Regulation
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 539253(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1956).
Ref 525568AL-8810: a novel prostaglandin F2 alpha analog with selective antagonist effects at the prostaglandin F2 alpha (FP) receptor. J Pharmacol Exp Ther. 1999 Sep;290(3):1278-84.

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