Drug Information

Drug General Information
Drug ID
D06CDQ
Former ID
DNC000940
Drug Name
Methyllycaconitine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540622]
Formula
C37H50N2O10
InChI
InChI=1S/C37H50N2O10/c1-7-38-17-34(18-49-32(42)20-10-8-9-11-23(20)39-26(40)14-19(2)31(39)41)13-12-25(46-4)36-22-15-21-24(45-3)16-35(43,27(22)28(21)47-5)37(44,33(36)38)30(48-6)29(34)36/h8-11,19,21-22,24-25,27-30,33,43-44H,7,12-18H2,1-6H3/t19-,21+,22+,24-,25-,27+,28-,29+,30-,33-,34-,35+,36-,37+/m0/s1
InChIKey
XLTANAWLDBYGFU-VTLKBQQISA-N
CAS Number
CAS 21019-30-7
PubChem Compound ID
5288811
PubChem Substance ID
7888940, 39321132, 46393942, 57359244, 76728079, 103059184, 125333241, 125333248, 178100806, 178100831, 210024584
Target and Pathway
Target(s) Neuronal acetylcholine receptor protein, alpha-7 chain Target Info Antagonist [535293], [535398]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Cholinergic synapse
Nicotine addiction
Chemical carcinogenesis
PANTHER Pathway Alzheimer disease-amyloid secretase pathway
Nicotinic acetylcholine receptor signaling pathway
Reactome Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
WikiPathways SIDS Susceptibility Pathways
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
References
Ref 540622(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4005).
Ref 535293Experience of Black participants in the Lung Health Study smoking cessation intervention program. Nicotine Tob Res. 2001 Nov;3(4):375-82.
Ref 535398Nicotine increases the expression of high affinity nerve growth factor receptors in both in vitro and in vivo. Life Sci. 2002 Feb 15;70(13):1543-54.

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