Drug Information

Drug General Information
Drug ID
D0E9UX
Former ID
DIB020680
Drug Name
PF3845
Synonyms
PF-3845; PF 3845
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540711]
Structure
Download
2D MOL
Formula
C24H23F3N4O2
InChI
InChI=1S/C24H23F3N4O2/c25-24(26,27)19-6-7-22(29-15-19)33-21-5-1-3-18(14-21)13-17-8-11-31(12-9-17)23(32)30-20-4-2-10-28-16-20/h1-7,10,14-17H,8-9,11-13H2,(H,30,32)
InChIKey
NBOJHRYUGLRASX-UHFFFAOYSA-N
PubChem Compound ID
25154867
PubChem Substance ID
57248831, 89867374, 122258738, 124971390, 125082367, 125333676, 126731464, 136349540, 136367671, 137275975, 152258571, 160647406, 162011494, 162038083, 162202773, 163137237, 163893798, 164194106, 164764180, 172657437, 174526520, 175612295, 177748654, 178101927, 186007059, 198964764, 215779244, 223370353, 223617455, 223705225, 240486031, 242059920, 251963208, 251971338, 252110163, 252157847, 252160387, 252216045, 252451266
Target and Pathway
Target(s) Fatty-acid amide hydrolase Target Info Inhibitor [530091]
BioCyc Pathway Anandamide degradation
KEGG Pathway Retrograde endocannabinoid signaling
PANTHER Pathway Anandamide degradation
References
Ref 540711(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5243).
Ref 530091Discovery and characterization of a highly selective FAAH inhibitor that reduces inflammatory pain. Chem Biol. 2009 Apr 24;16(4):411-20.

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