Drug General Information |
Drug ID |
D0GE8X
|
Former ID |
DNC000720
|
Drug Name |
H-1152P
|
Drug Type |
Small molecular drug
|
Indication |
Discovery agent
|
Investigative |
[1]
|
Structure |
|
Download
2D MOL
3D MOL
|
Formula |
C16H23Cl2N3O2S
|
Canonical SMILES |
CC1CNCCCN1S(=O)(=O)C2=CC=CC3=CN=CC(=C32)C.Cl.Cl
|
InChI |
1S/C16H21N3O2S.2ClH/c1-12-9-18-11-14-5-3-6-15(16(12)14)22(20,21)19-8-4-7-17-10-13(19)2;;/h3,5-6,9,11,13,17H,4,7-8,10H2,1-2H3;2*1H/t13-;;/m1../s1
|
InChIKey |
BFOPDSJOLUQULZ-FFXKMJQXSA-N
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PubChem Compound ID |
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PubChem Substance ID |
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Target and Pathway |
Target(s) |
Rho-associated protein kinase 1 |
Target Info |
Inhibitor |
[1]
|
KEGG Pathway
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cGMP-PKG signaling pathway
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cAMP signaling pathway
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Chemokine signaling pathway
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Sphingolipid signaling pathway
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Vascular smooth muscle contraction
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TGF-beta signaling pathway
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Axon guidance
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Focal adhesion
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Platelet activation
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Leukocyte transendothelial migration
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Regulation of actin cytoskeleton
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Oxytocin signaling pathway
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Pathogenic Escherichia coli infection
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Shigellosis
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Salmonella infection
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Pathways in cancer
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Proteoglycans in cancer
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MicroRNAs in cancer
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PANTHER Pathway
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Cytoskeletal regulation by Rho GTPase
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Inflammation mediated by chemokine and cytokine signaling pathway
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CCKR signaling map ST
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Pathway Interaction Database
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Signaling events mediated by PRL
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RhoA signaling pathway
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Noncanonical Wnt signaling pathway
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EPHB forward signaling
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Thromboxane A2 receptor signaling
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PAR4-mediated thrombin signaling events
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amb2 Integrin signaling
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Integrins in angiogenesis
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EPHA forward signaling
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Stabilization and expansion of the E-cadherin adherens junction
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Signaling events mediated by VEGFR1 and VEGFR2
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PAR1-mediated thrombin signaling events
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N-cadherin signaling events
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Reactome
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Apoptotic cleavage of cellular proteins
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EPHB-mediated forward signaling
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EPHA-mediated growth cone collapse
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G alpha (12/13) signalling events
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Sema4D induced cell migration and growth-cone collapse
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VEGFA-VEGFR2 Pathway
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RHO GTPases Activate ROCKs
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WikiPathways
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G13 Signaling Pathway
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Regulation of Actin Cytoskeleton
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EGF/EGFR Signaling Pathway
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TGF beta Signaling Pathway
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Focal Adhesion
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JAK/STAT
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AGE/RAGE pathway
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Pathogenic Escherichia coli infection
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Regulation of Microtubule Cytoskeleton
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Leptin signaling pathway
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Semaphorin interactions
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Integrin-mediated Cell Adhesion
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GPCR downstream signaling
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Apoptotic execution phase
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MicroRNAs in cardiomyocyte hypertrophy
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Androgen receptor signaling pathway
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References |
REF 1 | The novel and specific Rho-kinase inhibitor (S)-(+)-2-methyl-1-[(4-methyl-5-isoquinoline)sulfonyl]-homopiperazine as a probing molecule for Rho-kinase-involved pathway. Pharmacol Ther. 2002 Feb-Mar;93(2-3):225-32. |