Drug Information

Drug General Information
Drug ID
D04YNW
Former ID
DNC000350
Drug Name
BRL 52537 hydrochloride
Drug Type
Small molecular drug
Indication Discovery agent Investigative [535870]
Structure
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2D MOL

3D MOL
Formula
C18H25Cl3N2O
Canonical SMILES
C1CCN(C(C1)CN2CCCC2)C(=O)CC3=CC(=C(C=C3)Cl)Cl.Cl
InChI
1S/C18H24Cl2N2O.ClH/c19-16-7-6-14(11-17(16)20)12-18(23)22-10-2-1-5-15(22)13-21-8-3-4-9-21;/h6-7,11,15H,1-5,8-10,12-13H2;1H
InChIKey
NGVLSOWJSUUYDE-UHFFFAOYSA-N
PubChem Compound ID
11315337
PubChem Substance ID
16404595, 17405697, 23480767, 24278716, 42394690, 50107062, 52415579, 53778247, 56463467, 91703265, 92303331, 123100674, 134339796, 135372722, 135698168, 136379554, 152049710, 152212294, 152254728, 152344428, 160840400, 162011471, 163099635, 163565095, 172093635, 172096435, 172870784, 174473416, 180672643, 184594793, 185981674, 204420262, 223378425, 223434978, 233947597, 241181833, 242060373, 249741609, 249847349, 250179619, 250201211, 252033978, 252215065, 252315895, 252430933
Target and Pathway
Target(s) Kappa-type opioid receptor Target Info Agonist [535870]
KEGG Pathway Neuroactive ligand-receptor interaction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Opioid prodynorphin pathway
Reactome Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 535870Kappa-opioid receptor selectivity for ischemic neuroprotection with BRL 52537 in rats. Anesth Analg. 2003 Dec;97(6):1776-83.
Ref 535870Kappa-opioid receptor selectivity for ischemic neuroprotection with BRL 52537 in rats. Anesth Analg. 2003 Dec;97(6):1776-83.

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