Drug General Information
Drug ID
D0Z3XJ
Former ID
DNC007081
Drug Name
3-(2-(naphthalen-2-ylmethyl)phenyl)acrylic acid
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528393]
Structure
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2D MOL

3D MOL

Formula
C20H16O2
Canonical SMILES
C1=CC=C2C=C(C=CC2=C1)CC3=CC=CC=C3C=CC(=O)O
InChI
1S/C20H16O2/c21-20(22)12-11-17-6-2-4-8-19(17)14-15-9-10-16-5-1-3-7-18(16)13-15/h1-13H,14H2,(H,21,22)/b12-11+
InChIKey
MOLQZQYMXCCLHS-VAWYXSNFSA-N
PubChem Compound ID
Target and Pathway
Target(s) Prostaglandin E2 receptor, EP4 subtype Target Info Inhibitor [528393]
Prostaglandin E2 receptor EP3 subtype Target Info Inhibitor [528393]
Prostaglandin E2receptor, EP2 subtype Target Info Inhibitor [528393]
KEGG Pathway Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
Renin secretion
Pathways in cancerhsa04020:Calcium signaling pathway
cAMP signaling pathway
Regulation of lipolysis in adipocytes
Pathways in cancerhsa04024:cAMP signaling pathway
Pathways in cancer
NetPath Pathway FSH Signaling Pathway
IL2 Signaling Pathway
IL4 Signaling Pathway
TGF_beta_Receptor Signaling PathwayNetPath_14:IL2 Signaling Pathway
Reactome Prostanoid ligand receptors
G alpha (s) signalling eventsR-HSA-391908:Prostanoid ligand receptors
G alpha (i) signalling eventsR-HSA-391908:Prostanoid ligand receptors
G alpha (s) signalling events
WikiPathways Prostaglandin Synthesis and Regulation
GPCRs, Class A Rhodopsin-like
Vitamin D Receptor Pathway
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signalingWP98:Prostaglandin Synthesis and Regulation
Ovarian Infertility Genes
GPCR downstream signaling
References
Ref 528393Bioorg Med Chem Lett. 2006 Nov 1;16(21):5639-42. Epub 2006 Aug 22.Comparison between two classes of selective EP(3) antagonists and their biological activities.
Ref 528393Bioorg Med Chem Lett. 2006 Nov 1;16(21):5639-42. Epub 2006 Aug 22.Comparison between two classes of selective EP(3) antagonists and their biological activities.

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