Drug Information
Drug General Information | |||||
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Drug ID |
D0T8CE
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Former ID |
DNCL002631
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Drug Name |
AMG888/U3-1287
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Indication | Non-small cell lung cancer [ICD10:C33-C34] | Phase 1/2 | [1] | ||
Company |
Amgen
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Target and Pathway | |||||
Target(s) | Receptor protein-tyrosine kinase erbB-3 | Target Info | Modulator | [2] | |
KEGG Pathway | ErbB signaling pathway | ||||
Calcium signaling pathway | |||||
Endocytosis | |||||
Proteoglycans in cancer | |||||
MicroRNAs in cancer | |||||
NetPath Pathway | TNFalpha Signaling Pathway | ||||
PANTHER Pathway | Cadherin signaling pathway | ||||
EGF receptor signaling pathway | |||||
Pathway Interaction Database | ErbB2/ErbB3 signaling events | ||||
ErbB receptor signaling network | |||||
a6b1 and a6b4 Integrin signaling | |||||
WikiPathways | ErbB Signaling Pathway | ||||
Apoptosis-related network due to altered Notch3 in ovarian cancer | |||||
Signaling Pathways in Glioblastoma | |||||
miR-targeted genes in muscle cell - TarBase | |||||
Heart Development | |||||
References | |||||
REF 1 | ClinicalTrials.gov (NCT01211483) Study of Erlotinib With or Without Investigational Drug (U3-1287) in Subjects With Advanced Non-small Cell Lung Cancer. U.S. National Institutes of Health. | ||||
REF 2 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1798). | ||||
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