Drug General Information
Drug ID	D08ZDD
Former ID	DNC005837
Drug Name	N-Hydroxy-4-(4-methoxy-phenyl)-4-oxo-butyramide
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[527800]
Structure		Download 2D MOL 3D MOL
Formula	C11H13NO4
Canonical SMILES	COC1=CC=C(C=C1)C(=O)CCC(=O)NO
InChI	1S/C11H13NO4/c1-16-9-4-2-8(3-5-9)10(13)6-7-11(14)12-15/h2-5,15H,6-7H2,1H3,(H,12,14)
InChIKey	YUAIIHPYXRCTLQ-UHFFFAOYSA-N
PubChem Compound ID	44404461
Target and Pathway
Target(s)	Interstitial collagenase	Target Info	Inhibitor	[527800]
KEGG Pathway	PPAR signaling pathway
	Pathways in cancer
	Bladder cancer
	Rheumatoid arthritis
NetPath Pathway	IL1 Signaling Pathway
	EGFR1 Signaling Pathway
	TWEAK Signaling Pathway
	Wnt Signaling Pathway
PANTHER Pathway	Alzheimer disease-presenilin pathway
	Plasminogen activating cascade
Pathway Interaction Database	Endothelins
	Validated transcriptional targets of AP1 family members Fra1 and Fra2
	Glucocorticoid receptor regulatory network
	AP-1 transcription factor network
	Syndecan-1-mediated signaling events
Reactome	Collagen degradation
	Degradation of the extracellular matrix
	Activation of Matrix Metalloproteinases
	Basigin interactions
	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
WikiPathways	TGF beta Signaling Pathway
	Bladder Cancer
	Activation of Matrix Metalloproteinases
	Degradation of collagen
	Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis
	Oncostatin M Signaling Pathway
	Prostate Cancer
	Integrated Breast Cancer Pathway
	Integrated Cancer pathway
	Cell surface interactions at the vascular wall
	Matrix Metalloproteinases
References
Ref 527800	J Med Chem. 2005 Oct 20;48(21):6585-96.Receptor flexibility in de novo ligand design and docking.
Ref 527800	J Med Chem. 2005 Oct 20;48(21):6585-96.Receptor flexibility in de novo ligand design and docking.

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