Drug Information

Drug General Information
Drug ID
D04EEU
Former ID
DNC000518
Drug Name
Dazoxiben
Drug Type
Small molecular drug
Indication Discovery agent Terminated [468236], [544646]
Structure
Download
2D MOL

3D MOL
Formula
C12H12N2O3
InChI
InChI=1S/C12H12N2O3/c15-12(16)10-1-3-11(4-2-10)17-8-7-14-6-5-13-9-14/h1-6,9H,7-8H2,(H,15,16)
InChIKey
XQGZSYKGWHUSDH-UHFFFAOYSA-N
CAS Number
CAS 1866-16-6
PubChem Compound ID
53001
PubChem Substance ID
6464175, 8182878, 11108723, 11138618, 16885502, 34717149, 46506407, 47927333, 50065204, 50101662, 50104198, 50483402, 57313477, 81041103, 90484147, 103167962, 104171390, 104301059, 118313769, 124884287, 125357718, 126684376, 129725579, 131326443, 132154930, 134223649, 134339926, 135049275, 135143057, 137021274, 141563666, 144204410, 160966204, 162178976, 162277685, 162770661, 163693520, 164788305, 165445590, 172886732, 178101865, 179071730, 186019504, 198967903, 206246230, 223681589, 223704361, 224873128, 226402235, 252347854
Target and Pathway
Target(s) Thromboxane-A synthase Target Info Inhibitor [537729]
BioCyc Pathway C20 prostanoid biosynthesis
KEGG Pathway Arachidonic acid metabolism
Metabolic pathways
Platelet activation
PathWhiz Pathway Arachidonic Acid Metabolism
WikiPathways Prostaglandin Synthesis and Regulation
Arachidonic acid metabolism
Phase 1 - Functionalization of compounds
Eicosanoid Synthesis
References
Ref 468236(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5175).
Ref 544646Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000420)
Ref 537729Metabolic protection of the reperfused canine endocardium by the thromboxane synthetase inhibitor, dazoxiben. Prostaglandins Leukot Essent Fatty Acids. 1988 Jul;33(1):13-22.

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