Drug Information

Drug General Information
Drug ID
D0P1UX
Former ID
DAP000054
Drug Name
Venlafaxine
Synonyms
Efectin; Elafax; Venlafaxina; VenlafaxineXR; Venlafaxinum; Venlafaxine ER; Wy 45030; Efectin (TN); Venlafaxina [INN-Spanish];Venlafaxine (Effexor); Venlafaxine (INN); Venlafaxine [BAN:INN]; Venlafaxine [INN:BAN]; Venlafaxinum [INN-Latin]; N,N-dimethyl-2-(1-hydroxycyclohexyl)-2-(4-methoxyphenyl)ethylamine; 1-[(1R)-2-(Dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexanol; 1-[2-(Dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexanol; 1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexan-1-ol; 1-[2-dimethylamino-1-(4-methoxyphenyl)ethyl]cyclohexan-1-ol; 1-{2-(dimethylamino)-1-[4-(methyloxy)phenyl]ethyl}cyclohexanol
Drug Type
Small molecular drug
Indication Depression [ICD9: 311; ICD10:F30-F39] Approved [537533], [542345]
Therapeutic Class
Antidepressants
Company
Wyeth
Structure
Download
2D MOL

3D MOL
Formula
C17H27NO2
InChI
InChI=1S/C17H27NO2/c1-18(2)13-16(17(19)11-5-4-6-12-17)14-7-9-15(20-3)10-8-14/h7-10,16,19H,4-6,11-13H2,1-3H3
InChIKey
PNVNVHUZROJLTJ-UHFFFAOYSA-N
CAS Number
CAS 93413-69-5
PubChem Compound ID
5656
PubChem Substance ID
9396, 5430653, 7980876, 8153474, 11342113, 11362296, 11364565, 11367127, 11369689, 11371976, 11374728, 11377851, 11484319, 11487698, 11488358, 11490804, 11492929, 11495485, 15222119, 17425507, 26612651, 26679955, 26748923, 26748924, 29224693, 46504593, 47583253, 48029197, 48416696, 49958155, 50107485, 51004905, 57288870, 57322883, 85787821, 85789257, 90341232, 92124669, 92307842, 92309100, 92714246, 94568830, 96025353, 103188954, 103923614, 104309869, 117865170, 118043482, 124637412, 124891843
ChEBI ID
ChEBI:9943
SuperDrug ATC ID
N06AX16
SuperDrug CAS ID
cas=093413695
Target and Pathway
Target(s) Sodium-dependent serotonin transporter Target Info Inhibitor [537422]
Sodium-dependent noradrenaline transporter Target Info Inhibitor [537422]
KEGG Pathway Serotonergic synapse
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway 5HT1 type receptor mediated signaling pathway
5HT2 type receptor mediated signaling pathway
5HT3 type receptor mediated signaling pathway
5HT4 type receptor mediated signaling pathwayP00001:Adrenaline and noradrenaline biosynthesis
Reactome Na+/Cl- dependent neurotransmitter transporters
WikiPathways Monoamine Transport
SIDS Susceptibility Pathways
NRF2 pathway
Synaptic Vesicle Pathway
Serotonin Transporter ActivityWP727:Monoamine Transport
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
References
Ref 537533Desvenlafaxine in the treatment of major depressive disorder. Neuropsychiatr Dis Treat. 2009;5:127-36. Epub 2009 Apr 8.
Ref 542345(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7321).
Ref 537422Clinically relevant drug interactions with new generation antidepressants and antipsychotics. Ther Umsch. 2009 Jun;66(6):485-92.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.