Drug Information

Drug General Information
Drug ID
D0S7BK
Former ID
DNC001065
Drug Name
Orotic acid
Drug Type
Small molecular drug
Indication Discovery agent Investigative [467930]
Structure
Download
2D MOL

3D MOL
Formula
C5H4N2O4
InChI
InChI=1S/C5H4N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h1H,(H,9,10)(H2,6,7,8,11)
InChIKey
PXQPEWDEAKTCGB-UHFFFAOYSA-N
CAS Number
CAS 65-86-1
PubChem Compound ID
967
PubChem Substance ID
3589, 75164, 595884, 605292, 798786, 823683, 823686, 823696, 823698, 828981, 833549, 833554, 834609, 836839, 836843, 838458, 838851, 841447, 3134136, 3154676, 4583105, 5466129, 7847123, 7889608, 8013736, 8020780, 8027091, 8137966, 8144922, 8150894, 10531957, 10589301, 15120234, 16877294, 16956134, 17388814, 22394337, 22394342, 22394347, 22394367, 24439324, 24897967, 26709670, 46504149, 46504235, 46508903, 48423871, 48425464, 48426230, 49737846
ChEBI ID
ChEBI:16742
Target and Pathway
Target(s) Dihydroorotate dehydrogenase, mitochondrial Target Info Inhibitor [537699]
KEGG Pathway Pyrimidine metabolism
Metabolic pathways
PathWhiz Pathway Pyrimidine Metabolism
Reactome Pyrimidine biosynthesis
WikiPathways Metabolism of nucleotides
References
Ref 467930(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4690).
Ref 537699Structure-activity relationships of pyrimidines as dihydroorotate dehydrogenase inhibitors. Biochem Pharmacol. 1988 Oct 15;37(20):3807-16.

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