Drug Information

Drug General Information
Drug ID
D0J3AO
Former ID
DNC004418
Drug Name
PD-160946
Drug Type
Small molecular drug
Indication Discovery agent Investigative [551281]
Structure
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2D MOL

3D MOL
Formula
C29H41FN4O4
Canonical SMILES
CC(C)C(C1=CC=CC=C1)OC(=O)NC(C)(CC2=CC=CC=C2F)C(=O)NCCCC<br />CCCNC(=O)N
InChI
1S/C29H41FN4O4/c1-21(2)25(22-14-8-7-9-15-22)38-28(37)34-29(3,20-23-16-10-11-17-24(23)30)26(35)32-18-12-5-4-6-13-19-33-27(31)36/h7-11,14-17,21,25H,4-6,12-13,18-20H2,1-3H3,(H,32,35)(H,34,37)(H3,31,33,36)/t25-,29+/m0/s1
InChIKey
ZAYADERDILOEBG-ABYGYWHVSA-N
PubChem Compound ID
9914897
Target and Pathway
Target(s) Nigral tachykinin NK(3) receptor Target Info Inhibitor [551281]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Reactome G alpha (q) signalling events
WikiPathways Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 551281The development of a novel series of non-peptide tachykinin NK3 receptor selective antagonists, Bioorg. Med. Chem. Lett. 5(16):1773-1778 (1995).
Ref 551281The development of a novel series of non-peptide tachykinin NK3 receptor selective antagonists, Bioorg. Med. Chem. Lett. 5(16):1773-1778 (1995).

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