Drug General Information
Drug ID	D09YHQ
Former ID	DNC008056
Drug Name	9-chlorobenzo[h]isoquinolin-1(2H)-one
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[529069]
Structure		Download 2D MOL 3D MOL
Formula	C13H8ClNO
Canonical SMILES	C1=CC2=C(C3=C1C=CC(=C3)Cl)C(=O)NC=C2
InChI	1S/C13H8ClNO/c14-10-4-3-8-1-2-9-5-6-15-13(16)12(9)11(8)7-10/h1-7H,(H,15,16)
InChIKey	XSQDWQSZUGGKPF-UHFFFAOYSA-N
PubChem Compound ID	11993732
Target and Pathway
Target(s)	Serine/threonine-protein kinase Chk1	Target Info	Inhibitor	[529069]
KEGG Pathway	Cell cycle
	p53 signaling pathway
	HTLV-I infection
	Viral carcinogenesis
Pathway Interaction Database	Fanconi anemia pathway
	p73 transcription factor network
	ATR signaling pathway
	Circadian rhythm pathway
	p53 pathway
Reactome	Activation of ATR in response to replication stress
	Processing of DNA double-strand break ends
	Presynaptic phase of homologous DNA pairing and strand exchange
	G2/M DNA damage checkpoint
	Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
	Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
WikiPathways	DNA Damage Response
	Signaling by SCF-KIT
	ATM Signaling Pathway
	Retinoblastoma (RB) in Cancer
	Integrated Pancreatic Cancer Pathway
	Prostate Cancer
	Integrated Breast Cancer Pathway
	Integrated Cancer pathway
	Cell Cycle
	Cell Cycle Checkpoints
	miRNA Regulation of DNA Damage Response
References
Ref 529069	Bioorg Med Chem Lett. 2007 Nov 15;17(22):6280-5. Epub 2007 Sep 7.Synthesis and evaluation of substituted benzoisoquinolinones as potent inhibitors of Chk1 kinase.
Ref 529069	Bioorg Med Chem Lett. 2007 Nov 15;17(22):6280-5. Epub 2007 Sep 7.Synthesis and evaluation of substituted benzoisoquinolinones as potent inhibitors of Chk1 kinase.

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