Drug Information

Drug General Information
Drug ID
D0M2BB
Former ID
DNC006668
Drug Name
1-(4-(1H-pyrazol-1-yl)benzyl)-4-phenylpiperazine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528099]
Structure
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2D MOL

3D MOL
Formula
C20H22N4
Canonical SMILES
C1CN(CCN1CC2=CC=C(C=C2)N3C=CC=N3)C4=CC=CC=C4
InChI
1S/C20H22N4/c1-2-5-19(6-3-1)23-15-13-22(14-16-23)17-18-7-9-20(10-8-18)24-12-4-11-21-24/h1-12H,13-17H2
InChIKey
PKQSDHHTBMYENT-UHFFFAOYSA-N
PubChem Compound ID
25333445
Target and Pathway
Target(s) D(3) dopamine receptor Target Info Inhibitor [528099]
D(2) dopamine receptor Target Info Inhibitor [528099]
D(4) dopamine receptor Target Info Inhibitor [528099]
Dopamine D1 receptor Target Info Inhibitor [528099]
KEGG Pathway Neuroactive ligand-receptor interaction
Dopaminergic synapsehsa04015:Rap1 signaling pathway
cAMP signaling pathway
Gap junction
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Alcoholismhsa04080:Neuroactive ligand-receptor interaction
Dopaminergic synapsehsa04020:Calcium signaling pathway
Amphetamine addiction
Morphine addiction
Alcoholism
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Nicotine pharmacodynamics pathwayP05912:Dopamine receptor mediated signaling pathway
PathWhiz Pathway Dopamine Activation of Neurological Reward System
Reactome Dopamine receptors
G alpha (i) signalling eventsR-HSA-390651:Dopamine receptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
Nicotine Activity on Dopaminergic Neurons
GPCRs, OtherWP666:Hypothetical Network for Drug Addiction
Genes and (Common) Pathways Underlying Drug Addiction
Nicotine Activity on Dopaminergic NeuronsWP666:Hypothetical Network for Drug Addiction
References
Ref 528099Bioorg Med Chem Lett. 2006 Jun 1;16(11):2955-9. Epub 2006 Mar 24.Synthesis and biological investigations of dopaminergic partial agonists preferentially recognizing the D4 receptor subtype.
Ref 528099Bioorg Med Chem Lett. 2006 Jun 1;16(11):2955-9. Epub 2006 Mar 24.Synthesis and biological investigations of dopaminergic partial agonists preferentially recognizing the D4 receptor subtype.

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