Drug Information

Drug General Information
Drug ID
D07KWZ
Former ID
DIB020160
Drug Name
L-367,773
Synonyms
L-367773; L 367773
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539422]
Structure
Download
2D MOL
Formula
C28H38N4O3S
InChI
InChI=1S/C28H38N4O3S/c1-26(2)21-8-10-28(26,24(15-21)31-25(33)16-22-17-29-19-30-22)18-36(34,35)32-13-11-27(12-14-32)9-7-20-5-3-4-6-23(20)27/h3-6,17,19,21,24H,7-16,18H2,1-2H3,(H,29,30)(H,31,33)/t21-,24+,28-/m1/s1
InChIKey
VQAVBHLGXVZOKM-RASJMTDNSA-N
PubChem Compound ID
10413997
PubChem Substance ID
15431702, 42244068, 80724336, 103363365, 103974665, 135650469
Target and Pathway
Target(s) Oxytocin receptor Target Info Antagonist [533590]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Oxytocin signaling pathway
NetPath Pathway TGF_beta_Receptor Signaling Pathway
PANTHER Pathway Oxytocin receptor mediated signaling pathway
Reactome Vasopressin-like receptors
G alpha (q) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Myometrial Relaxation and Contraction Pathways
Oxytocin signaling
Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 539422(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2246).
Ref 533590Characterization of the human oxytocin receptor stably expressed in 293 human embryonic kidney cells. Life Sci. 1995;57(24):2253-61.

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