Drug Information

Drug General Information
Drug ID
D0B1GJ
Former ID
DNC009361
Drug Name
11-Propionyloxy-N-n-propylnoraporphine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529686]
Structure
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2D MOL

3D MOL
Formula
C22H25NO2
Canonical SMILES
CCCN1CCC2=CC=CC3=C2C1CC4=C3C(=CC=C4)OC(=O)CC
InChI
1S/C22H25NO2/c1-3-12-23-13-11-15-7-5-9-17-21(15)18(23)14-16-8-6-10-19(22(16)17)25-20(24)4-2/h5-10,18H,3-4,11-14H2,1-2H3/t18-/m1/s1
InChIKey
FKAOLIWLWAYCIA-GOSISDBHSA-N
PubChem Compound ID
44578927
Target and Pathway
Target(s) 5-hydroxytryptamine 2A receptor Target Info Inhibitor [529686]
Dopamine D1 receptor Target Info Inhibitor [529686]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channelshsa04020:Calcium signaling pathway
cAMP signaling pathway
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Amphetamine addiction
Morphine addiction
Alcoholism
PANTHER Pathway 5HT2 type receptor mediated signaling pathwayP05912:Dopamine receptor mediated signaling pathway
PathWhiz Pathway Dopamine Activation of Neurological Reward System
Reactome Serotonin receptors
G alpha (q) signalling eventsR-HSA-390651:Dopamine receptors
G alpha (s) signalling events
WikiPathways Serotonin Receptor 2 and STAT3 Signaling
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
GPCRs, OtherWP666:Hypothetical Network for Drug Addiction
Genes and (Common) Pathways Underlying Drug Addiction
References
Ref 529686Bioorg Med Chem. 2008 Sep 15;16(18):8335-8. Epub 2008 Aug 28.N-Propylnoraporphin-11-O-yl carboxylic esters as potent dopamine D(2) and serotonin 5-HT(1A) receptor dual ligands.
Ref 529686Bioorg Med Chem. 2008 Sep 15;16(18):8335-8. Epub 2008 Aug 28.N-Propylnoraporphin-11-O-yl carboxylic esters as potent dopamine D(2) and serotonin 5-HT(1A) receptor dual ligands.

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