Drug Information

Drug General Information
Drug ID
D0X2NO
Former ID
DIB018062
Drug Name
(+)-ADTN
Synonyms
(+)-ADTN (aminotetralin-6,7-diol)
Drug Type
Small molecular drug
Indication Discovery agent Investigative [543307]
Structure
Download
2D MOL
Formula
C10H13NO2
InChI
InChI=1S/C10H13NO2/c11-8-2-1-6-4-9(12)10(13)5-7(6)3-8/h4-5,8,12-13H,1-3,11H2
InChIKey
ASXGAOFCKGHGMF-UHFFFAOYSA-N
PubChem Compound ID
3153
PubChem Substance ID
4396597, 8152008, 11364921, 11367483, 11370045, 11373084, 11375645, 11378215, 15017255, 24714865, 26755674, 26755675, 29222295, 47365320, 47440382, 47515425, 47515426, 47662414, 47736607, 48035255, 48035256, 48185101, 50064875, 50111036, 50111037, 52533724, 57321638, 85208928, 90340878, 92310038, 99300950, 103197355, 103805117, 103925217, 104302678, 117616121, 124749696, 124879796, 124879797, 124879798, 124879799, 125570003, 126686686, 127454619, 132611435, 135072376, 135649897, 162866432, 163667276, 163882663
Target and Pathway
Target(s) Dopamine D1 receptor Target Info Agonist [529311]
D(1B) dopamine receptor Target Info Agonist [529311]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Amphetamine addiction
Morphine addiction
Alcoholismhsa04020:Calcium signaling pathway
PANTHER Pathway Dopamine receptor mediated signaling pathwayP05912:Dopamine receptor mediated signaling pathway
PathWhiz Pathway Dopamine Activation of Neurological Reward System
Reactome Dopamine receptors
G alpha (s) signalling eventsR-HSA-390651:Dopamine receptors
G alpha (s) signalling events
WikiPathways Hypothetical Network for Drug Addiction
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Genes and (Common) Pathways Underlying Drug Addiction
GPCR ligand binding
GPCR downstream signalingWP58:Monoamine GPCRs
GPCR downstream signaling
References
Ref 543307(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 932).
Ref 529311Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1. Nature. 1991 Apr 18;350(6319):614-9.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.