Drug Information

Drug General Information
Drug ID
D00VXM
Former ID
DIB019782
Drug Name
droxinostat
Synonyms
NS-41080; NS41080
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530619]
Structure
Download
2D MOL
Formula
C11H14ClNO3
InChI
InChI=1S/C11H14ClNO3/c1-8-7-9(12)4-5-10(8)16-6-2-3-11(14)13-15/h4-5,7,15H,2-3,6H2,1H3,(H,13,14)
InChIKey
JHSXDAWGLCZYSM-UHFFFAOYSA-N
PubChem Compound ID
568416
PubChem Substance ID
3395519, 4294610, 7976312, 8089390, 8683016, 11177099, 12240829, 16777079, 17457418, 40378155, 47868302, 48769034, 49763171, 74777775, 87926768, 99437145, 105767842, 113490614, 117934896, 121361124, 124757236, 124781334, 124889779, 125164040, 130982904, 131480871, 134964552, 136340192, 136367418, 136367960, 136946693, 137052797, 139550249, 144047742, 144115925, 152258505, 160644544, 160647340, 162011831, 162037593, 162202706, 164193979, 164914325, 169565171, 174531821, 175608163, 175614199, 179179626, 185965244, 228463896
Target and Pathway
Target(s) Histone deacetylase-3 Target Info Inhibitor [530619]
Histone Deacetylase 8 Target Info Inhibitor [530619]
Histone deacetylase 6 Target Info Inhibitor [530619]
KEGG Pathway Thyroid hormone signaling pathway
Alcoholism
Viral carcinogenesishsa05034:Alcoholism
Viral carcinogenesis
PANTHER Pathway Wnt signaling pathwayP00057:Wnt signaling pathway
Pathway Interaction Database Signaling events mediated by HDAC Class II
Signaling events mediated by HDAC Class I
Retinoic acid receptors-mediated signaling
Validated targets of C-MYC transcriptional repression
Regulation of retinoblastoma proteinhdac_classi_pathway:Signaling events mediated by HDAC Class Ihdac_classii_pathway:Signaling events mediated by HDAC Class II
Reactome NOTCH1 Intracellular Domain Regulates Transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
HDACs deacetylate histonesR-HSA-2122947:NOTCH1 Intracellular Domain Regulates Transcription
Assembly of the primary cilium
WikiPathways Integrated Pancreatic Cancer Pathway
Neural Crest Differentiation
Cell CycleWP2858:Ectoderm Differentiation
Cell Cycle
References
Ref 530619Selective inhibition of histone deacetylases sensitizes malignant cells to death receptor ligands. Mol Cancer Ther. 2010 Jan;9(1):246-56.
Ref 530619Selective inhibition of histone deacetylases sensitizes malignant cells to death receptor ligands. Mol Cancer Ther. 2010 Jan;9(1):246-56.

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