Drug General Information
Drug ID	D0G7TT
Former ID	DIB019694
Drug Name	D-AP4
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[538919]
Structure		Download 2D MOL
Formula	C4H10NO5P
InChI	InChI=1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)/t3-/m1/s1
InChIKey	DDOQBQRIEWHWBT-GSVOUGTGSA-N
PubChem Compound ID	1550579
PubChem Substance ID	11110720, 11113373, 11113374, 11545104, 32249998, 47736771, 47736772, 78666741, 92466464, 110473208, 117682322, 118503878, 124879122, 125329048, 131342580, 135650159, 140384205, 160671828, 162658134, 237693815, 241181545, 241375169, 244495148
Target and Pathway
Target(s)	Metabotropic glutamate receptor 8	Target Info	Agonist	[534561]
KEGG Pathway	Neuroactive ligand-receptor interaction
	Glutamatergic synapse
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Metabotropic glutamate receptor group III pathway
Reactome	G alpha (i) signalling events
	Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways	GPCRs, Class C Metabotropic glutamate, pheromone
	GPCR ligand binding
	GPCR downstream signaling
	GPCRs, Other
References
Ref 538919	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1443).
Ref 534561	Group III human metabotropic glutamate receptors 4, 7 and 8: molecular cloning, functional expression, and comparison of pharmacological properties in RGT cells. Brain Res Mol Brain Res. 1998 Jan;53(1-2):88-97.

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