Drug General Information
Drug ID
D0K6MI
Former ID
DIB018156
Drug Name
[125I]ICYP
Synonyms
[125I]iodocyanopindolol
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540989]
Structure
Download
2D MOL
Formula
C15H18IN3O2
InChI
InChI=1S/C15H18IN3O2/c1-9(2)18-7-10(20)8-21-13-5-3-4-11-14(13)15(16)12(6-17)19-11/h3-5,9-10,18-20H,7-8H2,1-2H3/i16-2
InChIKey
WGSPBWSPJOBKNT-RFLHHMENSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Beta-3 adrenergic receptor Target Info Agonist [526944]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
Endocytosis
Salivary secretion
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Beta3 adrenergic receptor signaling pathway
Reactome Adrenoceptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 540989(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 562).
Ref 526944Stereoselectivity for interactions of agonists and antagonists at mouse, rat and human beta3-adrenoceptors. Eur J Pharmacol. 2004 Jan 26;484(2-3):323-31.

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