Drug Information

Drug General Information
Drug ID
D03KYG
Former ID
DAP000810
Drug Name
Perindopril
Synonyms
ACEON; Coverex; Coversum; Coversyl; Prestarium; Coverene Cor; Cpd with unspecified MF; Aceon (TN); Acertil (TN); Armix (TN); Coverene (TN); Coverex (TN); Coversum (TN); DW-7950; Prestarium (TN); Prexanil (TN); Prexum (TN); Procaptan (TN); S-9490; SED-9490; McN-A-2833; Perindopril (USAN/INN); Ethyl N-{(2S)-1-[(2S,3aS,7aS)-2-carboxyoctahydro-1H-indol-1-yl]-1-oxopropan-2-yl}-L-norvalinate; (2S)-2-[(1S)-1-Carbethoxybutylamino]-1-oxopropyl-(2S,3aS,7aS)-perhydroindole-2-carboxylic acid; (2S,3aS,7aS)-1-[(2S)-2-[[(2S)-1-ethoxy-1-oxopentan-2-yl]amino]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic acid; (2S,3aS,7aS)-1-[(2S)-2-{[(2S)-1-ethoxy-1-oxopentan-2-yl]amino}propanoyl]octahydro-1H-indole-2-carboxylic acid
Drug Type
Small molecular drug
Indication Hypertension [ICD9: 401; ICD10:I10-I16] Approved [536361], [541508]
Therapeutic Class
Antihypertensive Agents
Structure
Download
2D MOL

3D MOL
Formula
C19H32N2O5
InChI
InChI=1S/C19H32N2O5/c1-4-8-14(19(25)26-5-2)20-12(3)17(22)21-15-10-7-6-9-13(15)11-16(21)18(23)24/h12-16,20H,4-11H2,1-3H3,(H,23,24)/t12-,13-,14-,15-,16-/m0/s1
InChIKey
IPVQLZZIHOAWMC-QXKUPLGCSA-N
CAS Number
CAS 107133-36-8
PubChem Compound ID
107807
PubChem Substance ID
9908, 7980282, 10234445, 11364904, 11367466, 11370028, 11372525, 11374329, 11378198, 11484952, 11488924, 11491498, 11492590, 11495762, 12013509, 14755214, 14803882, 17397842, 44436758, 46508767, 48035415, 48259509, 48416399, 50065440, 53787258, 53801152, 56463760, 57338263, 78106573, 85788931, 93166944, 103589744, 104379782, 121363719, 124800274, 126655685, 128203001, 134338091, 134358176, 135047729, 137002499, 143493278, 144206638, 152235952, 152344316, 160964132, 162178238, 163137224, 170464836, 175265414
ChEBI ID
ChEBI:8025
SuperDrug ATC ID
C09AA04
SuperDrug CAS ID
cas=082834160
Target and Pathway
Target(s) Angiotensin-converting enzyme Target Info Inhibitor [537450]
KEGG Pathway Renin-angiotensin system
Chagas disease (American trypanosomiasis)
Hypertrophic cardiomyopathy (HCM)
PathWhiz Pathway Angiotensin Metabolism
Reactome Metabolism of Angiotensinogen to Angiotensins
WikiPathways ACE Inhibitor Pathway
Metabolism of Angiotensinogen to Angiotensins
References
Ref 536361Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20.
Ref 541508(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6367).
Ref 537450Fixed combination perindopril-amlodipine (Coveram) in the treatment of hypertension and coronary heart disease. Rev Med Liege. 2009 Apr;64(4):223-7.

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