Drug General Information
Drug ID	D0WZ9T
Former ID	DNC000409
Drug Name	CGP-44532
Drug Type	Small molecular drug
Indication	Drug abuse [ICD9: 303-304; ICD10:F10-F19]		Investigative	[538664]
Structure		Download 2D MOL 3D MOL
Formula	C4H12NO3P
InChI	InChI=1S/C4H12NO3P/c1-9(7,8)3-4(6)2-5/h4,6H,2-3,5H2,1H3,(H,7,8)/t4-/m1/s1
InChIKey	FUUPFUIGNBPCAY-SCSAIBSYSA-N
PubChem Compound ID	5310934
PubChem Substance ID	7978465, 11056152, 15321653, 39340682, 50007089, 53786187, 57359295, 76745741, 103334317, 114154878, 135650069, 224991769, 226545787
Target and Pathway
Target(s)	Gamma-aminobutyric acid B receptor	Target Info	Agonist	[534908], [536166]
KEGG Pathway	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	GABAergic synapse
	Estrogen signaling pathway
	Morphine addiction
Reactome	Activation of G protein gated Potassium channels
	G alpha (i) signalling events
	Class C/3 (Metabotropic glutamate/pheromone receptors)
	Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
WikiPathways	GPCRs, Class C Metabotropic glutamate, pheromone
	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
	Potassium Channels
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 538664	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1082).
Ref 534908	Inhibition of transient LES relaxations and reflux in ferrets by GABA receptor agonists. Am J Physiol. 1999 Oct;277(4 Pt 1):G867-74.
Ref 536166	Glutamate- and GABA-based CNS therapeutics. Curr Opin Pharmacol. 2006 Feb;6(1):7-17.

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