Drug Information

Drug General Information
Drug ID
D01TKB
Former ID
DCL000377
Drug Name
GSK424887
Drug Type
Small molecular drug
Indication Depression; Anxiety [ICD9: 300, 311; ICD10:F30-F39, F40-F42] Discontinued in Phase 1 [548690]
Company
GSK
Structure
Download
2D MOL

3D MOL
Formula
C33H44N6O5
Canonical SMILES
CC(C)CC(C(=O)NC(CC1=CN(C2=CC=CC=C21)C)C(=O)NC(CC3=CC=CC<br />=N3)C(=O)O)NC(=O)N4CCCCCC4
InChI
1S/C33H44N6O5/c1-22(2)18-26(37-33(44)39-16-10-4-5-11-17-39)30(40)35-27(19-23-21-38(3)29-14-7-6-13-25(23)29)31(41)36-28(32(42)43)20-24-12-8-9-15-34-24/h6-9,12-15,21-22,26-28H,4-5,10-11,16-20H2,1-3H3,(H,35,40)(H,36,41)(H,37,44)(H,42,43)/t26-,27+,28+/m0/s1
InChIKey
LIOKMIQQPDDTNO-UPRLRBBYSA-N
PubChem Compound ID
107810
PubChem Substance ID
7979321, 10234447, 11113960, 14838559, 44436760, 49866092, 50104760, 57338265, 77498989, 103429450, 104128375, 104379788, 134224728, 134339025, 134340029, 135065226, 135650284, 135698088, 184591604, 228261452, 241182233, 241375300, 249617269
Target and Pathway
Target(s) Substance-P receptor Target Info Antagonist [550963]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Measles
PANTHER Pathway CCKR signaling map ST
Reactome G alpha (q) signalling events
WikiPathways SIDS Susceptibility Pathways
Gastrin-CREB signalling pathway via PKC and MAPK
Spinal Cord Injury
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 548690Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800027682)
Ref 550963Clinical pipeline report, company report or official report of GlaxoSmithKline (2009).

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