Drug General Information
Drug ID
D02AYI
Former ID
DNC009583
Drug Name
2-(4-phenoxyphenoxy)ethanamine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529868]
Structure
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2D MOL

3D MOL

Formula
C14H15NO2
Canonical SMILES
C1=CC=C(C=C1)OC2=CC=C(C=C2)OCCN
InChI
1S/C14H15NO2/c15-10-11-16-12-6-8-14(9-7-12)17-13-4-2-1-3-5-13/h1-9H,10-11,15H2
InChIKey
FBLANPWAVFBRNS-UHFFFAOYSA-N
PubChem Compound ID
Target and Pathway
Target(s) Phospholipase A2, membrane associated Target Info Inhibitor [529868]
Leukotriene A-4 hydrolase Target Info Inhibitor [529770]
BioCyc Pathway PhospholipasesPWY66-375:Leukotriene biosynthesis
KEGG Pathway Glycerophospholipid metabolism
Ether lipid metabolism
Arachidonic acid metabolism
Linoleic acid metabolism
alpha-Linolenic acid metabolism
Metabolic pathways
Ras signaling pathway
Vascular smooth muscle contraction
Pancreatic secretion
Fat digestion and absorptionhsa00590:Arachidonic acid metabolism
Pathway Interaction Database Glypican 1 network
PathWhiz Pathway Arachidonic Acid Metabolism
Reactome Acyl chain remodelling of PC
Acyl chain remodelling of PE
Acyl chain remodelling of PI
WikiPathways Cardiac Hypertrophic Response
Glycerophospholipid biosynthesis
Glycerophospholipid Biosynthetic Pathway
Spinal Cord Injury
Eicosanoid Synthesis
MicroRNAs in cardiomyocyte hypertrophyWP2650:Arachidonic acid metabolism
References
Ref 529868J Med Chem. 2008 Dec 25;51(24):7882-8.Discovery of multitarget inhibitors by combining molecular docking with common pharmacophore matching.
Ref 529770Bioorg Med Chem Lett. 2008 Dec 15;18(24):6549-52. Epub 2008 Oct 14.Activation and inhibition of leukotriene A4 hydrolase aminopeptidase activity by diphenyl ether and derivatives.
Ref 529868J Med Chem. 2008 Dec 25;51(24):7882-8.Discovery of multitarget inhibitors by combining molecular docking with common pharmacophore matching.

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