Drug Information

Drug General Information
Drug ID
D0NL7J
Former ID
DNC013214
Drug Name
N1-(4-chlorobenzyl)-2-amino-N3-hydroxymalonamide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528703]
Structure
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2D MOL

3D MOL
Formula
C10H12ClN3O3
Canonical SMILES
C1=CC(=CC=C1CNC(=O)C(C(=O)NO)N)Cl
InChI
1S/C10H12ClN3O3/c11-7-3-1-6(2-4-7)5-13-9(15)8(12)10(16)14-17/h1-4,8,17H,5,12H2,(H,13,15)(H,14,16)
InChIKey
OGTJYIPAKYEFNR-UHFFFAOYSA-N
PubChem Compound ID
16115629
Target and Pathway
Target(s) Aminopeptidase N Target Info Inhibitor [528703]
BioCyc Pathway Glutathione-mediated detoxification
KEGG Pathway Glutathione metabolism
Metabolic pathways
Renin-angiotensin system
Hematopoietic cell lineage
Pathway Interaction Database C-MYB transcription factor network
PathWhiz Pathway Glutathione Metabolism
Reactome Metabolism of Angiotensinogen to Angiotensins
WikiPathways Metabolism of Angiotensinogen to Angiotensins
Cardiac Progenitor Differentiation
miR-targeted genes in squamous cell - TarBase
miR-targeted genes in muscle cell - TarBase
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in leukocytes - TarBase
Glutathione metabolism
References
Ref 528703J Med Chem. 2007 Mar 22;50(6):1322-34. Epub 2007 Feb 28.Novel selective inhibitors of the zinc plasmodial aminopeptidase PfA-M1 as potential antimalarial agents.
Ref 528703J Med Chem. 2007 Mar 22;50(6):1322-34. Epub 2007 Feb 28.Novel selective inhibitors of the zinc plasmodial aminopeptidase PfA-M1 as potential antimalarial agents.

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