Drug Information

Drug General Information
Drug ID
D04QHB
Former ID
DNC007118
Drug Name
2-cyclohexylamino-pyrimidine-4-carbonitrile
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528643]
Structure
Download
2D MOL

3D MOL
Formula
C11H14N4
Canonical SMILES
C1CCC(CC1)NC2=NC=CC(=N2)C#N
InChI
1S/C11H14N4/c12-8-10-6-7-13-11(15-10)14-9-4-2-1-3-5-9/h6-7,9H,1-5H2,(H,13,14,15)
InChIKey
SOIZAJGZULPDSF-UHFFFAOYSA-N
PubChem Compound ID
16108885
Target and Pathway
Target(s) Cathepsin K Target Info Inhibitor [528643]
KEGG Pathway Lysosome
Osteoclast differentiation
Toll-like receptor signaling pathway
Rheumatoid arthritis
NetPath Pathway TGF_beta_Receptor Signaling Pathway
RANKL Signaling Pathway
IL2 Signaling Pathway
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Trafficking and processing of endosomal TLR
MHC class II antigen presentation
WikiPathways RANKL/RANK Signaling Pathway
Osteoclast Signaling
References
Ref 528643J Med Chem. 2007 Feb 22;50(4):591-4. Epub 2007 Jan 27.2-Cyano-pyrimidines: a new chemotype for inhibitors of the cysteine protease cathepsin K.
Ref 528643J Med Chem. 2007 Feb 22;50(4):591-4. Epub 2007 Jan 27.2-Cyano-pyrimidines: a new chemotype for inhibitors of the cysteine protease cathepsin K.

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