Drug Information

Drug General Information
Drug ID
D00OMV
Former ID
DNC012128
Drug Name
ARTEMINOLIDE
Drug Type
Small molecular drug
Indication Discovery agent Investigative [526296]
Structure
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2D MOL

3D MOL
Formula
C37H46O7
Canonical SMILES
CC1=C2C(C3C(C(C1)CC(=O)CC(C)C)C4(CC56C=CC4(CC5C7C(CCC6(<br />C)O)C(=C)C(=O)O7)C)C(=O)O3)C(=CC2=O)C
InChI
1S/C37H46O7/c1-18(2)12-23(38)15-22-13-19(3)27-26(39)14-20(4)28(27)31-29(22)37(33(41)44-31)17-36-11-10-34(37,6)16-25(36)30-24(8-9-35(36,7)42)21(5)32(40)43-30/h10-11,14,18,22,24-25,28-31,42H,5,8-9,12-13,15-17H2,1-4,6-7H3/t22-,24+,25-,28?,29?,30?,31?,34-,35-,36?,37?/m1/s1
InChIKey
DXADJEQOLJUISX-OKVWKMHQSA-N
PubChem Compound ID
44282335
Target and Pathway
Target(s) Protein farnesyltransferase beta subunit Target Info Inhibitor [526296]
KEGG Pathway Terpenoid backbone biosynthesis
Biosynthesis of antibiotics
NetPath Pathway TSH Signaling Pathway
Reactome Inactivation, recovery and regulation of the phototransduction cascade
WikiPathways Visual phototransduction
References
Ref 526296J Med Chem. 2002 Mar 28;45(7):1460-5.Modeling of binding modes and inhibition mechanism of some natural ligands of farnesyl transferase using molecular docking.
Ref 526296J Med Chem. 2002 Mar 28;45(7):1460-5.Modeling of binding modes and inhibition mechanism of some natural ligands of farnesyl transferase using molecular docking.

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