Drug Information

Drug General Information
Drug ID
D0G8BN
Former ID
DNC004663
Drug Name
CAPSAZEPINE
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539589]
Structure
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2D MOL

3D MOL
Formula
C19H21ClN2O2S
InChI
InChI=1S/C19H21ClN2O2S/c20-16-5-3-13(4-6-16)7-8-21-19(25)22-9-1-2-14-10-17(23)18(24)11-15(14)12-22/h3-6,10-11,23-24H,1-2,7-9,12H2,(H,21,25)
InChIKey
DRCMAZOSEIMCHM-UHFFFAOYSA-N
PubChem Compound ID
2733484
PubChem Substance ID
3153122, 4689287, 7978851, 8794630, 11110887, 11113514, 11120274, 11120762, 11121250, 11121615, 11122095, 11362684, 11365246, 11367808, 11370639, 11370640, 11373409, 11375970, 14755701, 17404936, 24277967, 26751729, 26758380, 30091315, 47515104, 47810533, 48258992, 49688358, 49877927, 50104422, 50104423, 52479418, 53777479, 53790523, 56463490, 57409553, 71822557, 85084530, 85230948, 85788750, 90340779, 91611492, 92303760, 92309966, 99300878, 99302398, 103546395, 103904082, 111358572, 113635233
Target and Pathway
Target(s) Transient receptor potential cation channel subfamily V member 4 Target Info Inhibitor [526604]
Vanilloid receptor 1 Target Info Inhibitor [528825]
Vanilloid receptor Target Info Inhibitor [528825]
KEGG Pathway Inflammatory mediator regulation of TRP channelshsa04080:Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
NetPath Pathway IL2 Signaling Pathway
Pathway Interaction Database Trk receptor signaling mediated by the MAPK pathway
Trk receptor signaling mediated by PI3K and PLC-gamma
Reactome TRP channelsR-HSA-3295583:TRP channels
References
Ref 539589(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2461).
Ref 526604Bioorg Med Chem Lett. 2003 May 5;13(9):1549-52.Chain-branched acyclic phenethylthiocarbamates as vanilloid receptor antagonists.
Ref 528825J Med Chem. 2007 May 31;50(11):2589-96. Epub 2007 May 10.The potential of transient receptor potential vanilloid type 1 channel modulators for the treatment of pain.

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