Drug Information

Drug General Information
Drug ID
D01XMO
Former ID
DNC003683
Drug Name
LY-292728
Drug Type
Small molecular drug
Indication Discovery agent Terminated [546277]
Structure
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2D MOL

3D MOL
Formula
C34H29FO9
Canonical SMILES
CCC1=C(C=C(C(=C1)C2=CC=C(C=C2)F)O)OCCCOC3=C(C4=C(C=C3)C<br />(=O)C5=C(O4)C=CC(=C5)C(=O)O)CCC(=O)O
InChI
1S/C34H29FO9/c1-2-19-16-25(20-4-7-22(35)8-5-20)27(36)18-30(19)43-15-3-14-42-28-12-9-24-32(39)26-17-21(34(40)41)6-11-29(26)44-33(24)23(28)10-13-31(37)38/h4-9,11-12,16-18,36H,2-3,10,13-15H2,1H3,(H,37,38)(H,40,41)
InChIKey
DCTKEJXAVFAMFK-UHFFFAOYSA-N
PubChem Compound ID
192617
Target and Pathway
Target(s) Leukotriene B4 receptor 2 Target Info Inhibitor [533960]
Leukotriene B4 receptor 1 Target Info Inhibitor [533960]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interactionhsa04080:Neuroactive ligand-receptor interaction
NetPath Pathway IL4 Signaling Pathway
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathway
Reactome Leukotriene receptors
G alpha (q) signalling eventsR-HSA-391906:Leukotriene receptors
G alpha (q) signalling events
WikiPathways Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
GPCRs, OtherWP80:Nucleotide GPCRs
GPCRs, Class A Rhodopsin-like
Spinal Cord Injury
References
Ref 546277Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007211)
Ref 533960J Med Chem. 1993 Nov 26;36(24):3982-4.Biphenylyl-substituted xanthones: highly potent leukotriene B4 receptor antagonists.

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