Drug Information

Drug General Information
Drug ID
D0P0IE
Former ID
DNC001134
Drug Name
Plumbagin
Drug Type
Small molecular drug
Indication Discovery agent Investigative [542034]
Structure
Download
2D MOL

3D MOL
Formula
C11H8O3
InChI
InChI=1S/C11H8O3/c1-6-5-9(13)10-7(11(6)14)3-2-4-8(10)12/h2-5,12H,1H3
InChIKey
VCMMXZQDRFWYSE-UHFFFAOYSA-N
CAS Number
CAS 481-42-5
PubChem Compound ID
10205
PubChem Substance ID
12573, 133894, 521949, 603925, 894743, 3137729, 5161447, 8157354, 11406297, 11533356, 14748463, 24898833, 26612765, 26747815, 26747816, 26753709, 29204496, 29228728, 47217413, 47662928, 49759527, 49996654, 50100148, 50107298, 50107299, 51383330, 53790001, 56370727, 57326035, 57389148, 81092960, 85088824, 85789657, 87575243, 87643179, 99214999, 103222017, 103924486, 104322655, 124570932, 124891764, 125371034, 126647787, 129455362, 131315904, 134340370, 134974697, 137006725, 143366855, 143401484
ChEBI ID
ChEBI:8273
Target and Pathway
Target(s) Dihydroorotate dehydrogenase, mitochondrial Target Info Inhibitor [534955]
KEGG Pathway Pyrimidine metabolism
Metabolic pathways
PathWhiz Pathway Pyrimidine Metabolism
Reactome Pyrimidine biosynthesis
WikiPathways Metabolism of nucleotides
References
Ref 542034(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7003).
Ref 534955Kinetics of inhibition of human and rat dihydroorotate dehydrogenase by atovaquone, lawsone derivatives, brequinar sodium and polyporic acid. Chem Biol Interact. 2000 Jan 3;124(1):61-76.

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