Drug Information

Drug General Information
Drug ID
D0I0EG
Former ID
DAP000589
Drug Name
Captopril
Synonyms
Acediur; Aceplus; Acepress; Acepril; Alopresin; Apopril; Asisten; Capoten; Captolane; Captoprilum; Captopryl; Captoril; Captril; Cesplon; Dilabar; Garranil; Hipertil; Hypertil; Isopresol; Lopirin; Lopril; MCO; Tenosbon; Tensiomin; Tensobon; Tensoprel; Lopirin [Switzerland]; C 4042; SA 333; SQ 14225; X8Z; Apopril (TN); Capoten (TN); Captoprilum [INN-Latin]; Garranil (discontinued); L-Captopril; SQ 14,225; SQ-14225; SQ-14534; SQ-14,225; SQ-14,534; Captopril (JP15/USP/INN); Captopril [USAN:INN:BAN:JAN]; D-3-Mercapto-2-methylpropionylproline; D-2-Methyl-3-mercaptopropanoyl-L-proline; D-3-Mercapto-2-methylpropanoyl-L-proline; [2S]-1-[3-Mercapto-2-methylpropionyl]-L-proline; N-[(S)-3-Mercapto-2-methylpropionyl]-L-proline;(2S)-1-(3-Mercapto-2-methylpropionyl)-L-proline; (2S)-1-[(2S)-2-methyl-3-sulfanylpropanoyl]pyrrolidine-2-carboxylic acid; (S)-1-(3-Mercapto-2-methyl-1-oxo-propyl)-L-proline; (S)-1-(3-Mercapto-2-methyl-1-oxopropyl)-L-proline; 1-((2S)-3-Mercapto-2-methylpropionyl)-L-proline; 1-(3-Mercapto-2-methyl-1-oxopropyl)-L-proline; 1-(D-3-Mercapto-2-methyl-1-oxopropyl)-L-proline (S,S); 1-[(2S)-2-methyl-3-sulfanylpropanoyl]-L-proline; 3-Mercapto-2-methylpropionyl-proline
Drug Type
Small molecular drug
Indication Hypertension [ICD9: 401; ICD10:I10-I16] Approved [468221], [538272]
Therapeutic Class
Antihypertensive Agents
Company
Bristol-Myers Squibb
Structure
Download
2D MOL

3D MOL
Formula
C9H15NO3S
InChI
InChI=1S/C9H15NO3S/c1-6(5-14)8(11)10-4-2-3-7(10)9(12)13/h6-7,14H,2-5H2,1H3,(H,12,13)/t6-,7+/m1/s1
InChIKey
FAKRSMQSSFJEIM-RQJHMYQMSA-N
CAS Number
CAS 62571-86-2
PubChem Compound ID
44093
PubChem Substance ID
823180, 855925, 3154070, 7847317, 7978852, 8149632, 8178487, 10321204, 11110941, 11335383, 11360622, 11363582, 11366144, 11368706, 11372295, 11374460, 11376868, 11461594, 11484758, 11489027, 11491203, 11492626, 11494502, 11533495, 12013747, 14797867, 15195876, 17404865, 22391411, 24278149, 24893111, 26612024, 26679590, 26747043, 26747044, 26751563, 26758381, 34709396, 46392259, 46487953, 46506879, 47365058, 47440133, 47515193, 47515194, 47515195, 47736347, 47736348, 47959603, 49698307
ChEBI ID
ChEBI:3380
SuperDrug ATC ID
C09AA01
SuperDrug CAS ID
cas=062571862
Target and Pathway
Target(s) Angiotensin-converting enzyme Target Info Inhibitor [535533]
KEGG Pathway Renin-angiotensin system
Chagas disease (American trypanosomiasis)
Hypertrophic cardiomyopathy (HCM)
PathWhiz Pathway Angiotensin Metabolism
Reactome Metabolism of Angiotensinogen to Angiotensins
WikiPathways ACE Inhibitor Pathway
Metabolism of Angiotensinogen to Angiotensins
References
Ref 468221(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5158).
Ref 538272FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 074322.
Ref 535533Using ACE inhibitors appropriately. Am Fam Physician. 2002 Aug 1;66(3):461-8.

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