Drug Information

Drug General Information
Drug ID
D06CTE
Former ID
DAP000278
Drug Name
Imiquimod
Synonyms
Aldara; Beselna; Zartra; Zyclara; Imiquimod acetate; R 837; S 26308; Aldara (TN); Aldara, Imiquimod; Beselna (TN); DZ-2636; Imiquimod [USAN:INN]; MTD-39; R-837; S-26308; TMX-101; Imiquimod (JAN/USAN/INN); 1-(2-Methylpropyl)-1H-imidazole[4,5-c]quinoline-4-amine; 1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-amine; 1-(2-methylpropyl)imidazo[4,5-c]quinolin-4-amine; 1-isobutyl-1H-imidazo(4,5-c)quinolin-4-amine; 1-isobutyl-1H-imidazo[4,5-c]quinolin-4-amine; 3M Brand of Imiquimod; 4-Amino-1-isobutyl-1H-imidazo(4,5-c)quinoline; 4-Amino-1-isobutyl-1H-imidazo[4,5-c]quinoline
Drug Type
Small molecular drug
Indication Skin cancers [ICD9: 172, 173; ICD10:C43, C44] Approved [468123], [536772]
Therapeutic Class
Antiviral Agents
Company
INova Pharmaceuticals
Structure
Download
2D MOL

3D MOL
Formula
C14H16N4
InChI
InChI=1S/C14H16N4/c1-9(2)7-18-8-16-12-13(18)10-5-3-4-6-11(10)17-14(12)15/h3-6,8-9H,7H2,1-2H3,(H2,15,17)
InChIKey
DOUYETYNHWVLEO-UHFFFAOYSA-N
CAS Number
CAS 99011-02-6
PubChem Compound ID
57469
PubChem Substance ID
626307, 865810, 7740549, 8185255, 12013659, 14749564, 17396674, 17425421, 24724516, 25623636, 26752301, 26758924, 43115161, 46505394, 48426262, 49835865, 50065439, 53788646, 56313523, 57313902, 61128040, 74724996, 85174371, 87561300, 92309250, 92712277, 93167017, 99437194, 103396795, 104098475, 104312759, 117524043, 117779671, 118046220, 124757085, 124800125, 125163889, 125325444, 125360574, 126592901, 126630136, 126656817, 126670841, 127765602, 131331797, 131789979, 134337592, 135015330, 135698182, 136023845
ChEBI ID
ChEBI:36704
SuperDrug ATC ID
D06BB10
SuperDrug CAS ID
cas=099011026
Target and Pathway
Target(s) Toll-like receptor 7 Target Info Agonist [537456]
KEGG Pathway Toll-like receptor signaling pathway
Measles
Influenza A
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Toll receptor signaling pathway
Reactome Trafficking and processing of endosomal TLR
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
MyD88 dependent cascade initiated on endosome
WikiPathways Toll-like receptor signaling pathway
Toll-Like Receptors Cascades
MyD88 dependent cascade initiated on endosome
Trafficking and processing of endosomal TLR
Regulation of toll-like receptor signaling pathway
References
Ref 468123(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5003).
Ref 536772New drugs in development for the treatment of endometriosis. Expert Opin Investig Drugs. 2008 Aug;17(8):1187-202.
Ref 537456Imiquimod Enhances IFN-gamma Production and Effector Function of T Cells Infiltrating Human Squamous Cell Carcinomas of the Skin. J Invest Dermatol. 2009 Jun 11.

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