Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0X6IE
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| Former ID |
DNC009157
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| Drug Name |
4-amino-N-(4-sulfamoylbenzyl)benzenesulfonamide
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent | Investigative | [529948] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C13H15N3O4S2
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| Canonical SMILES |
C1=CC(=CC=C1CNS(=O)(=O)C2=CC=C(C=C2)N)S(=O)(=O)N
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| InChI |
1S/C13H15N3O4S2/c14-11-3-7-13(8-4-11)22(19,20)16-9-10-1-5-12(6-2-10)21(15,17)18/h1-8,16H,9,14H2,(H2,15,17,18)
|
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| InChIKey |
HHCXOFYGBAPOJR-UHFFFAOYSA-N
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Carbonic anhydrase VI | Target Info | Inhibitor | [529948] | |
| Carbonic anhydrase IX | Target Info | Inhibitor | [529948] | ||
| Carbonic anhydrase II | Target Info | Inhibitor | [530466] | ||
| Carbonic anhydrase | Target Info | Inhibitor | [529948] | ||
| Carbonic anhydrase I | Target Info | Inhibitor | [537461] | ||
| NetPath Pathway | IL4 Signaling Pathway | ||||
| EGFR1 Signaling Pathway | |||||
| Pathway Interaction Database | HIF-1-alpha transcription factor networkcmyb_pathway:C-MYB transcription factor network | ||||
| PathWhiz Pathway | Gastric Acid Production | ||||
| Reactome | Reversible hydration of carbon dioxideR-HSA-1234158:Regulation of gene expression by Hypoxia-inducible Factor | ||||
| Reversible hydration of carbon dioxideR-HSA-1237044:Erythrocytes take up carbon dioxide and release oxygen | |||||
| Erythrocytes take up oxygen and release carbon dioxide | |||||
| Reversible hydration of carbon dioxide | |||||
| WikiPathways | Reversible Hydration of Carbon DioxideWP2877:Vitamin D Receptor Pathway | ||||
| Reversible Hydration of Carbon Dioxide | |||||
| Regulation of Hypoxia-inducible Factor (HIF) by OxygenWP2770:Reversible Hydration of Carbon Dioxide | |||||
| Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes | |||||
| Uptake of Oxygen and Release of Carbon Dioxide by ErythrocytesWP2770:Reversible Hydration of Carbon Dioxide | |||||
| Uptake of Oxygen and Release of Carbon Dioxide by Erythrocytes | |||||
| References | |||||
| Ref 529948 | J Med Chem. 2009 Feb 12;52(3):646-54.Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV. | ||||
| Ref 530466 | Bioorg Med Chem Lett. 2009 Dec 1;19(23):6649-54. Epub 2009 Oct 7.Carbonic anhydrase inhibitors. Characterization and inhibition studies of the most active beta-carbonic anhydrase from Mycobacterium tuberculosis, Rv3588c. | ||||
| Ref 537461 | Carbonic anhydrase inhibitors. Inhibition studies of a coral secretory isoform by sulfonamides. Bioorg Med Chem. 2009 Jul 15;17(14):5054-8. Epub 2009 May 30. | ||||
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