Drug Information

Drug General Information
Drug ID
D08USC
Former ID
DNC014278
Drug Name
7-bromo-N-(3-bromophenyl)isoquinolin-1-amine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530473]
Structure
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2D MOL

3D MOL
Formula
C15H10Br2N2
Canonical SMILES
C1=CC(=CC(=C1)Br)NC2=NC=CC3=C2C=C(C=C3)Br
InChI
1S/C15H10Br2N2/c16-11-2-1-3-13(8-11)19-15-14-9-12(17)5-4-10(14)6-7-18-15/h1-9H,(H,18,19)
InChIKey
FGMDNVCIUONADU-UHFFFAOYSA-N
PubChem Compound ID
46879685
Target and Pathway
Target(s) Metabotropic glutamate receptor 5 Target Info Inhibitor [530473]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Huntington's disease
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group I pathway
Endogenous cannabinoid signaling
Reactome G alpha (q) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways Hypothetical Network for Drug Addiction
GPCRs, Class C Metabotropic glutamate, pheromone
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 530473Bioorg Med Chem Lett. 2009 Dec 1;19(23):6623-6. Epub 2009 Oct 9.Discovery and SAR of 6-substituted-4-anilinoquinazolines as non-competitive antagonists of mGlu5.
Ref 530473Bioorg Med Chem Lett. 2009 Dec 1;19(23):6623-6. Epub 2009 Oct 9.Discovery and SAR of 6-substituted-4-anilinoquinazolines as non-competitive antagonists of mGlu5.

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