TTD | Drug: D0R2CI

Drug General Information
Drug ID	D0R2CI
Former ID	DPR000052
Drug Name	GI-264879A
Drug Type	Small molecular drug
Indication	Obesity [ICD9: 278; ICD10:E66]		Preclinical	[536122]
Company	GSK
Structure		Download 2D MOL 3D MOL
Formula	C41H44F3N5O5
Canonical SMILES	COCC(CC1=CC=CC=C1)NC(=O)C(CCCN=C(N)N)NC(=O)CC(C2=CC=CC3<br />=CC=CC=C32)C4=CC=CC5=CC=CC=C54.C(=O)(C(F)(F)F)O
InChI	1S/C39H43N5O3.C2HF3O2/c1-47-26-30(24-27-12-3-2-4-13-27)43-38(46)36(22-11-23-42-39(40)41)44-37(45)25-35(33-20-9-16-28-14-5-7-18-31(28)33)34-21-10-17-29-15-6-8-19-32(29)34;3-2(4,5)1(6)7/h2-10,12-21,30,35-36H,11,22-26H2,1H3,(H,43,46)(H,44,45)(H4,40,41,42);(H,6,7)/t30-,36+;/m0./s1
InChIKey	NZGALICACGXBQM-HOBHVFGFSA-N
CAS Number	CAS 181110-62-3
PubChem Compound ID	9875299
PubChem Substance ID	14840230, 45622271, 76036362, 134339517
Target and Pathway
Target(s)	Neuropeptide Y receptor type 1	Target Info	Antagonist	[536122]
KEGG Pathway	cAMP signaling pathway
KEGG Pathway	Neuroactive ligand-receptor interaction
NetPath Pathway	FSH Signaling Pathway
Reactome	Peptide ligand-binding receptors
Reactome	G alpha (i) signalling events
WikiPathways	GPCRs, Class A Rhodopsin-like
	Peptide GPCRs
	Endothelin Pathways
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 536122	Emerging drugs for obesity: linking novel biological mechanisms to pharmaceutical pipelines. Expert Opin Emerg Drugs. 2005 Aug;10(3):643-60.
Ref 536122	Emerging drugs for obesity: linking novel biological mechanisms to pharmaceutical pipelines. Expert Opin Emerg Drugs. 2005 Aug;10(3):643-60.

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Drug Information