Drug Information

Drug General Information
Drug ID
D0M0ZB
Former ID
DNC014224
Drug Name
H-Ala-Pro-Phe-Phe-NH2
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530745]
Structure
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2D MOL

3D MOL
Formula
C26H33N5O4
Canonical SMILES
CC(C(=O)N1CCCC1C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CC3=CC=CC=C<br />3)C(=O)N)N
InChI
1S/C26H33N5O4/c1-17(27)26(35)31-14-8-13-22(31)25(34)30-21(16-19-11-6-3-7-12-19)24(33)29-20(23(28)32)15-18-9-4-2-5-10-18/h2-7,9-12,17,20-22H,8,13-16,27H2,1H3,(H2,28,32)(H,29,33)(H,30,34)/t17-,20+,21+,22+/m1/s1
InChIKey
PYBNVPBCTAEKPN-MNAPGUCWSA-N
PubChem Compound ID
46229263
Target and Pathway
Target(s) Substance-P receptor Target Info Inhibitor [530745]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Measles
PANTHER Pathway CCKR signaling map ST
Reactome G alpha (q) signalling events
WikiPathways SIDS Susceptibility Pathways
Gastrin-CREB signalling pathway via PKC and MAPK
Spinal Cord Injury
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 530745J Med Chem. 2010 Mar 25;53(6):2383-9.Discovery of dipeptides with high affinity to the specific binding site for substance P1-7.
Ref 530745J Med Chem. 2010 Mar 25;53(6):2383-9.Discovery of dipeptides with high affinity to the specific binding site for substance P1-7.

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