Drug Information

Drug General Information
Drug ID
D01MBR
Former ID
DNC005204
Drug Name
BMS-245782
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527291]
Structure
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2D MOL

3D MOL
Formula
C33H41N7O5
Canonical SMILES
CC1=C(C(C(=C(N1)C)C(=O)OC)C2=CC(=CC=C2)NC(=NCCCN3CCN(CC<br />3)C4=CC(=CC=C4)OC)NC#N)C(=O)OC
InChI
1S/C33H41N7O5/c1-22-28(31(41)44-4)30(29(23(2)37-22)32(42)45-5)24-9-6-10-25(19-24)38-33(36-21-34)35-13-8-14-39-15-17-40(18-16-39)26-11-7-12-27(20-26)43-3/h6-7,9-12,19-20,30,37H,8,13-18H2,1-5H3,(H2,35,36,38)
InChIKey
HDRYBCLMRKGHSG-UHFFFAOYSA-N
PubChem Compound ID
11505425
Target and Pathway
Target(s) Neuropeptide Y receptor type 1 Target Info Inhibitor [527291]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
NetPath Pathway FSH Signaling Pathway
Reactome Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
Endothelin Pathways
GPCR ligand binding
GPCR downstream signaling
References
Ref 527291Bioorg Med Chem Lett. 2004 Dec 20;14(24):5975-8.Isosteric N-arylpiperazine replacements in a series of dihydropyridine NPY1 receptor antagonists.
Ref 527291Bioorg Med Chem Lett. 2004 Dec 20;14(24):5975-8.Isosteric N-arylpiperazine replacements in a series of dihydropyridine NPY1 receptor antagonists.

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