Drug Information

Drug General Information
Drug ID
D03JPN
Former ID
DIB018720
Drug Name
A-582941
Synonyms
A582941; A 582941
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540611]
Structure
Download
2D MOL
Formula
C17H20N4
InChI
InChI=1S/C17H20N4/c1-20-9-14-11-21(12-15(14)10-20)17-8-7-16(18-19-17)13-5-3-2-4-6-13/h2-8,14-15H,9-12H2,1H3
InChIKey
GTMRUYCIJSNXGB-UHFFFAOYSA-N
PubChem Compound ID
11173546
PubChem Substance ID
16253579, 23365032, 42228286, 76737417, 126522398, 137143002, 163326818, 163419542, 163850881, 164210652, 172086781, 172880994, 178100821, 223401930, 225381212, 226971519, 249373462, 252161592, 252214305, 252475415
Target and Pathway
Target(s) Neuronal acetylcholine receptor protein, alpha-7 chain Target Info Agonist [529066]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Cholinergic synapse
Nicotine addiction
Chemical carcinogenesis
PANTHER Pathway Alzheimer disease-amyloid secretase pathway
Nicotinic acetylcholine receptor signaling pathway
Reactome Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
WikiPathways SIDS Susceptibility Pathways
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
References
Ref 540611(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3995).
Ref 529066Broad-spectrum efficacy across cognitive domains by alpha7 nicotinic acetylcholine receptor agonism correlates with activation of ERK1/2 and CREB phosphorylation pathways. J Neurosci. 2007 Sep 26;27(39):10578-87.

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