Drug Information

Drug General Information
Drug ID
D01UKV
Former ID
DNC009726
Drug Name
3-[1'-{4'-(Benzyloxy)-phenyl}]-quinuclidine-2-ene
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528993]
Structure
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2D MOL

3D MOL
Formula
C20H21NO
Canonical SMILES
C1CN2CCC1C(=C2)C3=CC=C(C=C3)OCC4=CC=CC=C4
InChI
1S/C20H21NO/c1-2-4-16(5-3-1)15-22-19-8-6-17(7-9-19)20-14-21-12-10-18(20)11-13-21/h1-9,14,18H,10-13,15H2
InChIKey
OKNMXSHKBLYYKN-UHFFFAOYSA-N
PubChem Compound ID
23653492
Target and Pathway
Target(s) Squalene synthetase Target Info Inhibitor [528993]
BioCyc Pathway Cholesterol biosynthesis II (via 24,25-dihydrolanosterol)
Cholesterol biosynthesis III (via desmosterol)
Cholesterol biosynthesis I
Superpathway of cholesterol biosynthesis
Epoxysqualene biosynthesis
KEGG Pathway Steroid biosynthesis
Metabolic pathways
Biosynthesis of antibiotics
PANTHER Pathway Cholesterol biosynthesis
PathWhiz Pathway Steroid Biosynthesis
Reactome Cholesterol biosynthesis
PPARA activates gene expression
Activation of gene expression by SREBF (SREBP)
WikiPathways Statin Pathway
Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Activation of Gene Expression by SREBP (SREBF)
SREBP signalling
Cholesterol Biosynthesis
Cholesterol biosynthesis
References
Ref 528993Antimicrob Agents Chemother. 2007 Nov;51(11):4049-61. Epub 2007 Aug 20.Quinuclidine derivatives as potential antiparasitics.
Ref 528993Antimicrob Agents Chemother. 2007 Nov;51(11):4049-61. Epub 2007 Aug 20.Quinuclidine derivatives as potential antiparasitics.

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