Drug Information

Drug General Information
Drug ID
D0RD6G
Former ID
DNC007966
Drug Name
7-ethynyl-6H-chromeno[4,3-b]quinoline-3,9-diol
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528822]
Structure
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2D MOL

3D MOL
Formula
C18H11NO3
Canonical SMILES
C#CC1=C2COC3=CC(=O)C=CC3=C2NC4=C1C=C(C=C4)O
InChI
1S/C18H11NO3/c1-2-12-14-7-10(20)4-6-16(14)19-18-13-5-3-11(21)8-17(13)22-9-15(12)18/h1,3-8,19-20H,9H2
InChIKey
KEQHESMVPUELBA-UHFFFAOYSA-N
PubChem Compound ID
11594463
Target and Pathway
Target(s) Steroid hormone receptor ERR1 Target Info Inhibitor [528822]
Reactome PPARA activates gene expression
Transcriptional activation of mitochondrial biogenesis
Nuclear Receptor transcription pathway
WikiPathways Mitochondrial Gene Expression
Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Nuclear Receptors
References
Ref 528822Bioorg Med Chem Lett. 2007 Jul 15;17(14):4053-6. Epub 2007 May 4.ERbeta ligands. Part 6: 6H-Chromeno[4,3-b]quinolines as a new series of estrogen receptor beta-selective ligands.
Ref 528822Bioorg Med Chem Lett. 2007 Jul 15;17(14):4053-6. Epub 2007 May 4.ERbeta ligands. Part 6: 6H-Chromeno[4,3-b]quinolines as a new series of estrogen receptor beta-selective ligands.

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