Drug Information

Drug General Information
Drug ID
D0S3WH
Former ID
DAP001454
Drug Name
Artemisinin
Synonyms
Arteannuin; Artemisine; Artemisinina; Artemisinine; Artemisininum; Artesin; Huanghuahaosu; Qinghaosu; Qinghosu; Quinghaosu; Artemisinin [INN]; Artemisinina [Spanish]; Artemisinine [French]; Artemisininum [Latin]; Qing Hau SU; Qing Hau Sau; Qing Hau Sau [Chinese]; Qinghaosu [Chinese]; Quing Hau Sau; Artemisinin (INN); Coartem, Artemisinin; Artemisia annua L., extract; GNF-PF-5671; GNF-Pf-5341; Octahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano(4,3-j)-1,2-benzodioxepin-10(3H)-one; (+)-Arteannuin; (+)-Artemisinin; (3R,5aS,6R,8aS,9R,12S,12aR)-3,6,9-trimethyloctahydro-3,12-epoxypyrano[4,3-j][1,2]benzodioxepin-10(3H)-one; (3R,5aS,6R,8aS,9R,12S,12aR)-Octahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano(4,3-j)-1,2-benzodioxepin-10(3H)-one; (5aS,6R,8aS,9R,12S,12aR)-3,6,9-trimethyloctahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10(3H)-one; 1,5,9-trimethyl-(1R,4S,5R,9R,12S,13R)-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecan-10-one; 3,6,9-trimethyloctahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10(3H)-one
Drug Type
Small molecular drug
Indication Malaria [ICD10:B54] Approved [536602]
Structure
Download
2D MOL

3D MOL
Formula
C15H22O5
Canonical SMILES
CC1CCC2C(C(=O)OC3C24C1CCC(O3)(OO4)C)C
InChI
1S/C15H22O5/c1-8-4-5-11-9(2)12(16)17-13-15(11)10(8)6-7-14(3,18-13)19-20-15/h8-11,13H,4-7H2,1-3H3/t8-,9-,10+,11+,13-,14?,15-/m1/s1
InChIKey
BLUAFEHZUWYNDE-DCJAHCNHSA-N
CAS Number
CAS 63968-64-9
PubChem Compound ID
452191
PubChem Substance ID
11729, 597201, 3154164, 8149879, 10321764, 11537742, 11538015, 14873071, 17396660, 22391483, 24263048, 24862236, 25621962, 26612376, 26679989, 26755288, 29203860, 46488006, 49681218, 49698524, 49834379, 50110885, 50110886, 57405324, 57649481, 79908771, 87560451, 92124957, 92125361, 92710903, 99301744, 99437070, 103914249, 104179191, 104644865, 108667034, 124636730, 124757138, 125163942, 126631402, 131480746, 135692091, 136367381, 136368092, 140607255, 144115625, 162249932, 163614422, 166223153, 176484289
SuperDrug ATC ID
P01BE01
SuperDrug CAS ID
cas=063968649
Target and Pathway
Target(s) Dihydroorotate dehydrogenase, mitochondrial Target Info Inhibitor [536602]
Sarcoplasmic/endoplasmic reticulum calcium ATPase Target Info Inhibitor [536602]
KEGG Pathway Pyrimidine metabolism
Metabolic pathways
PathWhiz Pathway Pyrimidine Metabolism
Reactome Pyrimidine biosynthesis
WikiPathways Metabolism of nucleotides
References
Ref 536602The fight against drug-resistant malaria: novel plasmodial targets and antimalarial drugs. Curr Med Chem. 2008;15(2):161-71.
Ref 536602The fight against drug-resistant malaria: novel plasmodial targets and antimalarial drugs. Curr Med Chem. 2008;15(2):161-71.

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