Drug Information

Drug General Information
Drug ID
D0VW0I
Former ID
DNC000499
Drug Name
Cyclopentenylcytosine
Drug Type
Small molecular drug
Indication Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48] Phase 1 [533634]
Structure
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2D MOL

3D MOL
Formula
C10H13N3O4
Canonical SMILES
C1=CN(C(=O)N=C1N)C2C=C(C(C2O)O)CO
InChI
1S/C10H13N3O4/c11-7-1-2-13(10(17)12-7)6-3-5(4-14)8(15)9(6)16/h1-3,6,8-9,14-16H,4H2,(H2,11,12,17)/t6-,8-,9+/m1/s1
InChIKey
DUJGMZAICVPCBJ-VDAHYXPESA-N
CAS Number
CAS 90597-22-1
PubChem Compound ID
72828
PubChem Substance ID
469266, 606792, 8137392, 8195407, 11407920, 14970604, 43128902, 49684187, 50036789, 50220121, 57318846, 103137350, 103260024, 104353831, 117588189, 134223699, 134339910, 135030763, 162936475, 164150582, 198947333, 235688373, 241175085, 252449427
Target and Pathway
Target(s) CTP synthase Target Info Inhibitor [537918]
KEGG Pathway Pyrimidine metabolism
Metabolic pathways
PANTHER Pathway De novo pyrimidine ribonucleotides biosythesis
PathWhiz Pathway Pyrimidine Metabolism
WikiPathways Metabolism of nucleotides
References
Ref 533634Phase I clinical trial of continuous infusion cyclopentenyl cytosine. Cancer Chemother Pharmacol. 1995;36(6):513-23.
Ref 537918Molecular approaches for the treatment of hemorrhagic fever virus infections. Antiviral Res. 1993 Sep;22(1):45-75.

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