Drug Information

Drug General Information
Drug ID
D0Y5LX
Former ID
DNC010611
Drug Name
4-cyclohexyl-6-propylpyrimidine-2-carbonitrile
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530717]
Structure
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2D MOL

3D MOL
Formula
C14H19N3
Canonical SMILES
CCCC1=NC(=NC(=C1)C2CCCCC2)C#N
InChI
1S/C14H19N3/c1-2-6-12-9-13(17-14(10-15)16-12)11-7-4-3-5-8-11/h9,11H,2-8H2,1H3
InChIKey
WGTHPYHNMKDPLN-UHFFFAOYSA-N
PubChem Compound ID
11622731
Target and Pathway
Target(s) Cathepsin K Target Info Inhibitor [530717]
KEGG Pathway Lysosome
Osteoclast differentiation
Toll-like receptor signaling pathway
Rheumatoid arthritis
NetPath Pathway TGF_beta_Receptor Signaling Pathway
RANKL Signaling Pathway
IL2 Signaling Pathway
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Trafficking and processing of endosomal TLR
MHC class II antigen presentation
WikiPathways RANKL/RANK Signaling Pathway
Osteoclast Signaling
References
Ref 530717Bioorg Med Chem Lett. 2010 Mar 1;20(5):1524-7. Epub 2010 Jan 25.Design and optimization of a series of novel 2-cyano-pyrimidines as cathepsin K inhibitors.
Ref 530717Bioorg Med Chem Lett. 2010 Mar 1;20(5):1524-7. Epub 2010 Jan 25.Design and optimization of a series of novel 2-cyano-pyrimidines as cathepsin K inhibitors.

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