Drug Information

Drug General Information
Drug ID
D0I7SZ
Former ID
DAP000588
Drug Name
Quinapril
Synonyms
Ectren; Koretic; Quinaprilum; QUINAPRIL HCL; Quinaprilum [Latin]; Accupril (TN); Quinapril [INN:BAN]; Quinapril (USP/INN); [3S-[2[R*(R*)],3R*]]-2-[2-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-3-Isoquinolinecarboxylic acid; (3S)-2-(N-{(1S)-1-[(ethyloxy)carbonyl]-3-phenylpropyl}-L-alanyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; (3S)-2-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-3,4-dihydro-1H-isoquinoline-3-carboxylic acid; (3S)-2-{(2S)-2-[(1S)-1-ethoxycarbonyl-3-phenylpropylamino]propanoyl}-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; (3S)-2-{N-((S)-1-Ethoxycarbonyl-3-phenylpropyl)-L-alanyl}-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
Drug Type
Small molecular drug
Indication Hypertension [ICD9: 401; ICD10:I10-I16] Approved [536361], [541494]
Therapeutic Class
Antihypertensive Agents
Company
Pfizer Pharmaceuticals
Structure
Download
2D MOL

3D MOL
Formula
C25H30N2O5
InChI
InChI=1S/C25H30N2O5/c1-3-32-25(31)21(14-13-18-9-5-4-6-10-18)26-17(2)23(28)27-16-20-12-8-7-11-19(20)15-22(27)24(29)30/h4-12,17,21-22,26H,3,13-16H2,1-2H3,(H,29,30)/t17-,21-,22-/m0/s1
InChIKey
JSDRRTOADPPCHY-HSQYWUDLSA-N
CAS Number
CAS 85441-61-8
PubChem Compound ID
54892
PubChem Substance ID
9602, 7980446, 8145927, 8149893, 8183841, 11335885, 11361124, 11364491, 11367053, 11369615, 11372621, 11374133, 11377777, 11462096, 11484485, 11488641, 11491366, 11492542, 11495411, 14759220, 14881354, 17397841, 34718828, 46506309, 47589015, 48035134, 48259244, 48416506, 49835285, 50065313, 50113005, 50113006, 50744269, 85787397, 92309221, 93166955, 99301798, 103590286, 104306102, 117576967, 121264493, 124893433, 126683866, 127334979, 127334980, 127334981, 127334982, 127334983, 127334984, 127334985
ChEBI ID
ChEBI:8713
SuperDrug ATC ID
C09AA06
SuperDrug CAS ID
cas=085441618
Target and Pathway
Target(s) Angiotensin-converting enzyme Target Info Inhibitor [537132]
KEGG Pathway Renin-angiotensin system
Chagas disease (American trypanosomiasis)
Hypertrophic cardiomyopathy (HCM)
PathWhiz Pathway Angiotensin Metabolism
Reactome Metabolism of Angiotensinogen to Angiotensins
WikiPathways ACE Inhibitor Pathway
Metabolism of Angiotensinogen to Angiotensins
References
Ref 536361Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20.
Ref 541494(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6350).
Ref 537132An experimental model of encapsulating peritoneal sclerosis. Perit Dial Int. 2009 Feb;29 Suppl 2:S49-50.

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