Drug General Information
Drug ID	D08NQW
Former ID	DIB019130
Drug Name	CHPG
Synonyms	2-chloro-5-hydroxyphenylglycine
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[538894]
Structure		Download 2D MOL
Formula	C8H8ClNO3
InChI	InChI=1S/C8H8ClNO3/c9-6-2-1-4(11)3-5(6)7(10)8(12)13/h1-3,7,11H,10H2,(H,12,13)
InChIKey	UNIDAFCQFPGYJJ-UHFFFAOYSA-N
PubChem Compound ID	3645780
PubChem Substance ID	4971876, 7978934, 9825754, 14748712, 37841240, 49878618, 53472200, 57356454, 85209021, 91746266, 99300569, 103397322, 103983726, 112087391, 126254323, 135650090, 137147522, 162022804, 162248184, 163125501, 179294118, 204377612, 219630404, 237693946, 241182082
Target and Pathway
Target(s)	Metabotropic glutamate receptor 5	Target Info	Agonist	[525911]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Gap junction
	Long-term potentiation
	Retrograde endocannabinoid signaling
	Glutamatergic synapse
	Huntington's disease
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Metabotropic glutamate receptor group III pathway
	Metabotropic glutamate receptor group I pathway
	Endogenous cannabinoid signaling
Reactome	G alpha (q) signalling events
	Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways	Hypothetical Network for Drug Addiction
	GPCRs, Class C Metabotropic glutamate, pheromone
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 538894	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1417).
Ref 525911	Characterization of [(3)H]Quisqualate binding to recombinant rat metabotropic glutamate 1a and 5a receptors and to rat and human brain sections. J Neurochem. 2000 Dec;75(6):2590-601.

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