Drug Information

Drug General Information
Drug ID
D0D3AS
Former ID
DNC004681
Drug Name
5-Nitro-2-(4-phenoxy-phenyl)-1H-benzoimidazole
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527477]
Structure
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2D MOL

3D MOL
Formula
C19H13N3O3
Canonical SMILES
C1=CC=C(C=C1)OC2=CC=C(C=C2)C3=NC4=C(N3)C=C(C=C4)[N+](=O<br />)[O-]
InChI
1S/C19H13N3O3/c23-22(24)14-8-11-17-18(12-14)21-19(20-17)13-6-9-16(10-7-13)25-15-4-2-1-3-5-15/h1-12H,(H,20,21)
InChIKey
ZBWXPJPIZQAKGA-UHFFFAOYSA-N
PubChem Compound ID
11325003
Target and Pathway
Target(s) Serine/threonine-protein kinase Chk2 Target Info Inhibitor [527477]
KEGG Pathway Cell cycle
p53 signaling pathway
HTLV-I infection
Pathway Interaction Database ATM pathway
FOXM1 transcription factor network
p53 pathway
PLK3 signaling events
Reactome Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
G2/M DNA damage checkpoint
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
WikiPathways DNA Damage Response
ATM Signaling Pathway
Integrated Pancreatic Cancer Pathway
Prostate Cancer
Integrated Breast Cancer Pathway
Integrated Cancer pathway
Cell Cycle
miRNA Regulation of DNA Damage Response
References
Ref 527477J Med Chem. 2005 Mar 24;48(6):1873-85.Checkpoint kinase inhibitors: SAR and radioprotective properties of a series of 2-arylbenzimidazoles.
Ref 527477J Med Chem. 2005 Mar 24;48(6):1873-85.Checkpoint kinase inhibitors: SAR and radioprotective properties of a series of 2-arylbenzimidazoles.

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